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Type:	Artigo de Periódico
Title:	Sympathetic autonomic denervation in heart failure: comparison of chagas? heart disease with other dilated cardiomyopathy
Authors:	Viviane Parisotto Marino Sandra Monetti Dumont Luciene Das Graças Mota Daniela Braga Stephanie Saliba de Freitas Maria da Consolação Vieira Moreira
Abstract:	Background: Heart failure (HF) is a severe public health problem because of its high morbidity and mortality and elevated costs, thus requiring better understanding of its course. In its complex and multifactorial pathogenesis, sympathetic hyperactivity plays a relevant role. Considering that sympathetic dysfunction is already present in the initial phases of chronic Chagas cardiomyopathy (CCC) and frequently associated with a worse prognosis, we assumed it could be more severe in CCC than in cardiomyopathies of other etiologies (non-CCC).Objectives: To assess the cardiac sympathetic dysfunction (123I-MIBG) of HF, comparing individuals with CCC to those with non-CCC, using heart transplant (HT) patients as denervated heart parameters.Methods: We assessed 76 patients with functional class II-VI HF, being 25 CCC (17 men), 25 non-CCC (14 men) and 26 HT (20 men), by use of cardiac 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy, estimating the early and late heart-to-mediastinum ratio (HMR) of 123I-MIBG uptake and cardiac washout (WO%). The 5% significance level was adopted in the statistical analysis.Results: The early and late HMR values were 1.73 ± 0.24 and 1.58 ± 0.27, respectively, in CCC, and 1.62 ± 0.21 and 1.44 ± 0.16 in non-CCC (p = NS), being, however, higher in HT patients (p < 0.001). The WO% values were 41.65 ± 21.4 (CCC), 47.37 ± 14.19% (non-CCC) and 43.29 ± 23.02 (HT), p = 0.057. The late HMR values showed a positive weak correlation with left ventricular ejection fraction (LVEF) in CCC and non-CCC (r = 0.42 and p = 0.045; and r = 0.49 and p = 0.015, respectively).Conclusion: Sympathetic hyperactivity (123I-MIBG) was evidenced in patients with class II-IV HF, LVEF < 45%, independently of the HF etiology, as compared to HT patients. (Arq Bras Cardiol. 2018; 111(2):182-190
Subject:	Heart Failure Primary Dysautonomias Chagas Cardiomyopathy Gated Blood-Pool Imaging 3-Iodobenzylguanidine
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS MED - DEPARTAMENTO DE ANATOMIA E IMAGEM MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.5935/abc.20180124
URI:	http://hdl.handle.net/1843/62754
Issue Date:	2017
metadata.dc.url.externa:	https://doi.org/10.5935/abc.20180124
metadata.dc.relation.ispartof:	Arquivos Brasileiros de Cardiologia
Appears in Collections:	Artigo de Periódico

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