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Type:	Artigo de Periódico
Title:	High prevalence of obesity in rheumatoid arthritis patients: association with disease activity, hypertension, dyslipidemia and diabetes, a multi-center study
Authors:	Maria Fernanda Brandão de Resende Guimarães Carlos Ewerton Maia Rodrigues Kirla Wagner Poti Gomes Carla Jorge Machado Claiton Viegas Brenol Susana Ferreira Krampe Nicole Pamplona Bueno de Andrade Adriana Maria Kakehasi
Abstract:	Introduction: Rheumatoid arthritis (RA) is a well-documented independent risk factor for cardiovascular disease.Obesity may provide an additional link between inflammation and accelerated atherosclerosis in RA.Objective: To evaluate the association between obesity and disease parameters and cardiovascular risk factors in RApatients.Method: Cross-sectional study of a cohort of RA patients from three Brazilian teaching hospitals. Information on demographics, clinical parameters and the presence of cardiovascular risk factors was collected. Blood pressure, weight,height and waist circumference (WC) were measured during the first consultation. Laboratory data were retrieved from medical records. Obesity was defined according to the NCEP/ATPIII and IDF guidelines. The prevalence of obesity was determined cross-sectionally. Disease activity was evaluated using the DAS28 system (remission < 2.6; low 2.6–3.1; moderate 3.2–5.0; high > 5.1).Results: The sample consisted of 791 RA patients aged 54.7 ± 12.0 years, of whom 86.9% were women and 59.9% wereCaucasian. The mean disease duration was 12.8 ± 8.9 years. Three quarters were rheumatoid factor-positive, the mean body mass index (BMI) was 27.1 ± 4.9, and the mean WC was 93.5 ± 12.5 cm. The observed risk factors included dyslipidemia(34.3%), type-2 diabetes (15%), hypertension (49.2%) and family history of premature cardiovascular disease (16.5%). BMI defined obesity was highly prevalent (26.9%) and associated with age, hypertension and dyslipidemia. Increased WC was associated with diabetes, hypertension, dyslipidemia and disease activity. Conclusion: Obesity was highly prevalent in RA patients and associated with disease activity
Subject:	Arthritis, Rheumatoid Hypertension Dyslipidemia Diabetes
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.1186/s42358-019-0089-1
URI:	http://hdl.handle.net/1843/63273
Issue Date:	2019
metadata.dc.url.externa:	https://doi.org/10.20947/S0102-3098a0099
metadata.dc.relation.ispartof:	Revista Brasileira De Estudos De População
Appears in Collections:	Artigo de Periódico

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