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DC Field | Value | Language |
---|---|---|
dc.creator | Pedro Pires Goulart Guimarães | pt_BR |
dc.creator | Celso Tarso Rodrigues Viana | pt_BR |
dc.creator | Luciana Xavier Pereira | pt_BR |
dc.creator | Sávio Morato Lacerda Gontijo | pt_BR |
dc.creator | Paula Peixoto Campos | pt_BR |
dc.creator | Silvia Passos Andrade | pt_BR |
dc.creator | Robson Augusto Souza dos Santos | pt_BR |
dc.creator | Rubén Dario Sinisterra Millán | pt_BR |
dc.date.accessioned | 2024-01-29T13:42:20Z | - |
dc.date.available | 2024-01-29T13:42:20Z | - |
dc.date.issued | 2022 | - |
dc.citation.volume | 19 | pt_BR |
dc.citation.issue | 6 | pt_BR |
dc.citation.spage | 676 | pt_BR |
dc.citation.epage | 685 | pt_BR |
dc.identifier.doi | https://doi.org/10.2174/1567201818666210729110127 | pt_BR |
dc.identifier.issn | 1875-5704 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/63455 | - |
dc.description.resumo | Background: Colorectal cancer (CRC) is the third most common cancer in the world. 5- Fluorouracil (5-FU) is a conventional and most effective drug used in the clinic for the treatment of CRC. However, the clinical use of 5-FU is limited due to the acquired resistance and systemic toxicity, such as hepatotoxicity and gastrointestinal toxicity. Objective: Recent advances in nanomedicine are being exploited to develop nanoparticle platforms to overcome resistance and therapeutic delivery of active molecules. Here, we developed 5-FU loaded sulfadiazine-poly(lactide-co-glycolide) nanoparticles (SUL-PLGA NPs) to be applied in the colorectal cancer model. Methods: We assessed the in vivo efficacy of the SUL-PLGA NPs to enhance the antitumor effect of 5-FU. Results: In vivo treatment with 5-FU-SUL-PLGA NPs significantly reduced tumor growth in a colon cancer xenograft model compared to free 5-FU and 5-FU loaded non-targeted NPs. Treatment with 5-FU-SUL-PLGA NPs also increased blood vessel diameters within tumors, which could act in conjunction to enhance antitumor efficacy. In addition, 5-FU-SUL-PLGA NPs significantly reduced liver mass and lung mass, which are the most common metastasis sites of CRC, and decreased liver hepatotoxicity compared to free 5-FU drug and 5-FU loaded non-targeted NPs. Conclusion: Our findings suggest that the use of 5-FU-SUL-PLGA NPs is a promising strategy to enhance 5-FU efficacy against CRC. | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA | pt_BR |
dc.publisher.department | ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA | pt_BR |
dc.publisher.department | ICB - DEPARTAMENTO DE PATOLOGIA | pt_BR |
dc.publisher.department | ICX - DEPARTAMENTO DE QUÍMICA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Current Drug Delivery | pt_BR |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | PLGA | pt_BR |
dc.subject | Polymeric nanoparticles | pt_BR |
dc.subject | Sulfonamide | pt_BR |
dc.subject | Drug delivery | pt_BR |
dc.subject | Colorectal cancer | pt_BR |
dc.subject | Cancer therapy | pt_BR |
dc.subject.other | Nanopartículas | pt_BR |
dc.subject.other | Câncer - Tratamento | pt_BR |
dc.subject.other | Cólon (Anatomia) - Câncer | pt_BR |
dc.subject.other | Sistema de distribuição de medicamentos | pt_BR |
dc.subject.other | Sistemas deliberados de drogas poliméricas | pt_BR |
dc.subject.other | Ácidos sulfônicos | pt_BR |
dc.title | Sulfonamide-functionalized polymeric nanoparticles for enhanced in vivo colorectal cancer therapy | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.eurekaselect.com/article/116952 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0003-4534-2779 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-9407-3870 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-7803-4345 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0003-2016-2210 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0001-7656-1849 | pt_BR |
Appears in Collections: | Artigo de Periódico |
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