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Type:	Artigo de Periódico
Title:	Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma
Authors:	Smitha Sammith Shetty Mohit Sharma Felipe Paiva Fonseca Raghu Radhakrishnan Pradyumna Jayaram Ankit Singh Tanwar Shama Prasada Kabekkodu Satyamoorthy Kapaettu
Abstract:	Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent to fibrosis in the onset of oral submucous fibrosis (OSF) and the role of EMT in its malignant transformation indicates a hitherto unexplored involvement of EMT. This review focuses on the role of EMT markers which are regulators of the EMT mediated complex network of molecular mechanisms involved in the pathogenesis of OSF and OSCC. Further the gene enrichment analysis and pathway analysis supports the association of the upregulated and downregulated genes in various EMT regulating pathways.
Subject:	Epithelial-mesenchymal transition Oral submucous fibrosis Squamous cell carcinoma of head and neck Transcription Factors Neoplasms Genes Down-regulation Up-regulation
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE CLÍNICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016%2Fj.jdsr.2020.07.002
URI:	http://hdl.handle.net/1843/63463
Issue Date:	22-Aug-2020
metadata.dc.url.externa:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452314/
metadata.dc.relation.ispartof:	Japanese dental science review
Appears in Collections:	Artigo de Periódico

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