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http://hdl.handle.net/1843/63469| Type: | Artigo de Periódico |
| Title: | Eccentric overload muscle damage is attenuated by a novel Angiotensin- (1-7) treatment |
| Authors: | Lenice Kappes Becker Nádia Totou Samara Moura Lucas Miranda Kangussu Rubén Dario Sinisterra Millán Maria Jose Campagnole dos Santo Daniel Coelho Daisy Motta Santos Robson Augusto Souza dos Santos |
| Abstract: | The development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46±0.64 vs. placebo 3.80±0.77 cm) and 24 h after exercise (3.07±0.71 vs. 3.73±0.58 cm placebo) and higher MS at 24 h (24±12 N) and 48 h (30±15 N) vs. placebo (-8±9 N and -10±9 N). The CK for Ang-(1-7) (0.5±0.1 and 0.9±0.2 U/L) were lower at 48 and 72 h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38±2.5 pg/ml) vs. placebo (45±2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise. |
| Subject: | Medicina esportiva Química farmacêutica Angiotensina Músculos - Ferimentos e lesões |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | EEF - DEPARTAMENTO DE ESPORTES ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE MORFOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1055/a-0633-8892 |
| URI: | http://hdl.handle.net/1843/63469 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0633-8892 |
| metadata.dc.relation.ispartof: | International Journal of Sports Medicine |
| Appears in Collections: | Artigo de Periódico |
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