1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/63469
Full metadata record
DC FieldValueLanguage
dc.creatorLenice Kappes Beckerpt_BR
dc.creatorNádia Totoupt_BR
dc.creatorSamara Mourapt_BR
dc.creatorLucas Miranda Kangussupt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorMaria Jose Campagnole dos Santopt_BR
dc.creatorDaniel Coelhopt_BR
dc.creatorDaisy Motta Santospt_BR
dc.creatorRobson Augusto Souza dos Santospt_BR
dc.date.accessioned2024-01-29T19:47:51Z-
dc.date.available2024-01-29T19:47:51Z-
dc.date.issued2018-
dc.citation.volume39pt_BR
dc.citation.issue10pt_BR
dc.citation.spage743pt_BR
dc.citation.epage748pt_BR
dc.identifier.doihttps://doi.org/10.1055/a-0633-8892pt_BR
dc.identifier.issn0172-4622pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63469-
dc.description.resumoThe development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46±0.64 vs. placebo 3.80±0.77 cm) and 24 h after exercise (3.07±0.71 vs. 3.73±0.58 cm placebo) and higher MS at 24 h (24±12 N) and 48 h (30±15 N) vs. placebo (-8±9 N and -10±9 N). The CK for Ang-(1-7) (0.5±0.1 and 0.9±0.2 U/L) were lower at 48 and 72 h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38±2.5 pg/ml) vs. placebo (45±2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE ESPORTESpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Sports Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPhysical performancept_BR
dc.subjectAngiotensin-(1-7)pt_BR
dc.subjectMuscular damagept_BR
dc.subject.otherMedicina esportivapt_BR
dc.subject.otherQuímica farmacêuticapt_BR
dc.subject.otherAngiotensinapt_BR
dc.subject.otherMúsculos - Ferimentos e lesõespt_BR
dc.titleEccentric overload muscle damage is attenuated by a novel Angiotensin- (1-7) treatmentpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0633-8892pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9462-5719pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0215-0662pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3678-118Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9483-4206pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3265-7838pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.