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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/64075
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dc.creatorSandro Soares Almeidapt_BR
dc.creatorFlávia Campos Corgosinhopt_BR
dc.creatorCarlos EN Amorimpt_BR
dc.creatorMarcos Fernandes Gregnanipt_BR
dc.creatorRaquel Munhoz da Silveira Campospt_BR
dc.creatorDeborah Cristina Landi Masquiopt_BR
dc.creatorPriscila de Lima Sanchespt_BR
dc.creatorAline de Piano Ganenpt_BR
dc.creatorJoão Bosco Pesqueropt_BR
dc.creatorAna Raimunda Dâmasopt_BR
dc.creatorMarco Tulio de Mellopt_BR
dc.creatorSergio Tufikpt_BR
dc.creatorRonaldo Carvalho Araújopt_BR
dc.date.accessioned2024-02-16T16:54:10Z-
dc.date.available2024-02-16T16:54:10Z-
dc.date.issued2017-
dc.citation.volume18pt_BR
dc.citation.issue2pt_BR
dc.identifier.doihttps://doi.org/10.1177/1470320317703451pt_BR
dc.identifier.issn1752-8976pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/64075-
dc.description.resumoIntroduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents.Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes.Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response.Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE ESPORTESpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of the Renin-Angiotensin-Aldosterone Systempt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectInterdisciplinary therapypt_BR
dc.subjectMetabolic syndromept_BR
dc.subjectObesitypt_BR
dc.subjectAngiotensin-converting enzymept_BR
dc.subjectPolymorphismpt_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherEnzima conversora da angiotensinapt_BR
dc.subject.otherPolimorfismo genéticopt_BR
dc.titleDifferent metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphismpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.sagepub.com/doi/10.1177/1470320317703451pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4392-0953pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8684-7290pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6169-745Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0187-6402pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6433-0816pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4507-632Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7675-7470pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3896-2208pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0095-4608pt_BR
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