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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/64800
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dc.creatorNatany Garcia Reispt_BR
dc.creatorNeusa Maria Zanonpt_BR
dc.creatorTatiana E. Koikept_BR
dc.creatorAudrei R. Santospt_BR
dc.creatorElen H. Miyabarapt_BR
dc.creatorIsis do Carmo Kettelhutpt_BR
dc.creatorLuiz Carlos Navegantespt_BR
dc.creatorAna Paula Assispt_BR
dc.creatorNatalia Lauterbachpt_BR
dc.creatorDawit Albieiro Pinheiro Gonçalvespt_BR
dc.creatorWilian de Assis Silveirapt_BR
dc.creatorHenrique J. N. Morganpt_BR
dc.creatorRafael Valentimpt_BR
dc.creatorLucas F. Almeidapt_BR
dc.creatorLilian do Carmo Heckpt_BR
dc.date.accessioned2024-02-27T16:21:23Z-
dc.date.available2024-02-27T16:21:23Z-
dc.date.issued2022-05-18-
dc.citation.volume13pt_BR
dc.citation.spage2175pt_BR
dc.citation.epage2187pt_BR
dc.identifier.doihttps://doi.org/10.1002/jcsm.12986pt_BR
dc.identifier.issn2190-6009pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/64800-
dc.description.resumoBackground Fetal stage is a critical developmental window for the skeletal muscle, but little information is available about the impact of maternal vitamin D (Vit. D) deficiency (VDD) on offspring lean mass development in the adult life of male and female animals. Methods Female rats (Wistar Hannover) were fed either a control (1000 IU Vit. D3/kg) or a VDD diet (0 IU Vit. D3/kg) for 6 weeks and during gestation and lactation. At weaning, male and female offspring were randomly separated and received a standard diet up to 180 days old. Results Vitamin D deficiency induced muscle atrophy in the male (M-VDD) offspring at the end of weaning, an effect that was reverted along the time. Following 180 days, fast-twitch skeletal muscles [extensor digitorum longus (EDL)] from the M-VDD showed a decrease (20%; P < 0.05) in the number of total fibres but an increase in the cross-sectional area of IIB (17%; P < 0.05), IIA (19%; P < 0.05) and IIAX (21%; P < 0.05) fibres. The fibre hypertrophy was associated with the higher protein levels of MyoD (73%; P < 0.05) and myogenin (55% %; P < 0.05) and in the number of satellite cells (128.8 ± 14 vs. 91 ± 7.6 nuclei Pax7 + in the M-CTRL; P < 0.05). M-VDD increased time to fatigue during ex vivo contractions of EDL muscles and showed an increase in the phosphorylation levels of IGF-1/insulin receptor and their downstream targets related to anabolic processes and myogenic activation, including Ser 473Akt and Ser 21/9GSK-3β. In such muscles, maternal VDD induced a compensatory increase in the content of calcitriol (two-fold; P < 0.05) and CYP27B1 (58%; P < 0.05), a metabolizing enzyme that converts calcidiol to calcitriol. Interestingly, most morphological and biochemical changes found in EDL were not observed in slow-twitch skeletal muscles (soleus) from the M-VDD group as well as in both EDL and soleus muscles from the female offspring. Conclusions These data show that maternal VDD selectively affects the development of type-II muscle fibres in male offspring rats but not in female offspring rats and suggest that the enhancement of their size and fatigue resistance in fast-twitch skeletal muscle (EDL) is probably due to a compensatory increase in the muscle content of Vit. D in the adult age.pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICApt_BR
dc.publisher.departmentEEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Musclept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectFetal programmingpt_BR
dc.subjectVitamin Dpt_BR
dc.subjectSkeletal musclept_BR
dc.subjectMuscle developmentpt_BR
dc.subjectHypertrophypt_BR
dc.subject.otherVitamina Dpt_BR
dc.subject.otherFetopt_BR
dc.subject.otherEsqueletopt_BR
dc.subject.otherMúsculospt_BR
dc.subject.otherHipertrofiapt_BR
dc.titleMaternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring ratspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/jcsm.12986pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0391-7255pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5738-9374pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6933-6598pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2621-3330pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6171-7940pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5062-4493pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2352-6449pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5731-1219pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9423-9965pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9366-2593pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2325-9571pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9034-5357pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9870-9469pt_BR
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