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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/65139
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dc.creatorManoela Domingues Martinspt_BR
dc.creatorMônica Simões Israelpt_BR
dc.creatorNathália de Almeida Freirept_BR
dc.creatorMaria Eduarda Zeraik Barretopt_BR
dc.creatorCeleste Sánchez-Romeropt_BR
dc.creatorThamiris de Castro Abrantespt_BR
dc.creatorRomán Carlospt_BR
dc.creatorLucas Guimarães Abreupt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorMário José Romañachpt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorBruno Augusto Benevenuto de Andradept_BR
dc.creatorJohn Lennon Silva Cunhapt_BR
dc.creatorAna Luiza Oliveira Corrêa Rozapt_BR
dc.creatorMichelle Agostinipt_BR
dc.creatorAline Corrêa Abrahãopt_BR
dc.creatorNathalie Henriques Silva Canedopt_BR
dc.creatorDenize D'azambuja Ramospt_BR
dc.creatorCristiane Bedran Militopt_BR
dc.creatorJosé Alcides Almeidade Arrudapt_BR
dc.creatorFlávia Sirotheau Correa Pontespt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorMarinez Bizarro Barrapt_BR
dc.creatorVirgilio Gonzales Zanellapt_BR
dc.creatorMarco Antonio Trevizani Martinspt_BR
dc.date.accessioned2024-03-04T20:35:20Z-
dc.date.available2024-03-04T20:35:20Z-
dc.date.issued2021-
dc.citation.volume50pt_BR
dc.citation.issue6pt_BR
dc.citation.spage548pt_BR
dc.citation.epage557pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.13205pt_BR
dc.identifier.issn09042512pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/65139-
dc.description.resumoBackground: The diagnosis of oral and maxillofacial mature T/NK-cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype with scarce available data describing their clinical and microscopic aspects. Therefore, in this study, we investigated a series of mature T/NK-cell neoplasms affecting this anatomical region and provided an updated literature review. Methods: Cases diagnosed as mature T/NK-cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Patients' clinical data were collected from their pathology forms. Results: A total of 22 cases were included in this study. Eleven (50%) consisted of extranodal NK/T-cell lymphomas, nasal type; eight (36.4%) were peripheral T-cell lymphomas, NOS; two (9.1%) were adult T-cell leukaemia/lymphomas, and one (4.5%) was an ALK-positive anaplastic large cell lymphoma. Overall, males predominated, with a mean age of 55.7 years. The palate was the most affected site (50%), and tumours usually presented as destructive and painful ulcers. EBV was present in all cases of extranodal NK/T-cell lymphoma nasal type but was absent in the other subtypes. Conclusion: Among mature T/NK-cell lymphomas of the oral and maxillofacial region, extranodal NK/T-cell lymphoma, nasal type and peripheral T-cell lymphoma, NOS predominated. Older men were the most affected patients, and this heterogeneous group of neoplasms has a very aggressive clinical behaviour.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral pathology & medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectLinfoma Journal of oral pathology & medicine esse titulo periodicopt_BR
dc.subject06 Mature t/nk-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative study fao clínica, odontopediatria busca dia 13/12/2023 acesso restrito assunto Lymphoma, T-Cellpt_BR
dc.subject.otherLymphoma, T-cellpt_BR
dc.subject.otherLymphoma, extranodal NK-T-cellpt_BR
dc.subject.otherLymphomapt_BR
dc.subject.otherLymphoma, non-Hodgkinpt_BR
dc.subject.otherMouthpt_BR
dc.subject.otherOropharynxpt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherUlcerpt_BR
dc.subject.otherEpstein-Barr virus infectionspt_BR
dc.subject.otherLeukemiapt_BR
dc.subject.otherLymphoma, large-cell, anaplasticpt_BR
dc.titleMature T/NK-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13205pt_BR
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