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http://hdl.handle.net/1843/65215| Tipo: | Artigo de Periódico |
| Título: | Improvements in Upper Extremity Function Following Intensive Training Are Independent of Corticospinal Tract Organization in Children With Unilateral Spastic Cerebral Palsy: A Clinical Randomized Trial |
| Autor(es): | Kathleen M. Friel Yannick Bleyenheuft Jason B. Carmel Talita Campos Andrew M. Gordon Claudio L. Ferre Marina de Brito Brandao Hsing-ching Kuo Karen Chin Ya-ching Hung Maxime T. Robert Veronique H. Flamand Ana Smorenburg |
| Resumen: | Background/Objectives: Intensive training of the more affected upper extremity (UE) has been shown to be effective for children with unilateral spastic cerebral palsy (USCP). Two types of UE training have been particularly successful: Constraint-Induced Movement Therapy (CIMT) and Bimanual training. Reorganization of the corticospinal tract (CST) early during development often occurs in USCP. Prior studies have suggested that children with an ipsilateral CST controlling the affected UE may improve less following CIMT than children with a contralateral CST. We tested the hypothesis that improvements in UE function after intensive training depend on CST laterality. Study Participants and Setting: Eighty-two children with USCP, age 5 years 10 months to 17 years, University laboratory setting. Materials/Methods: Single-pulse transcranial magnetic stimulation (TMS) was used to determine each child's CST connectivity pattern. Children were stratified by age, sex, baseline hand function and CST connectivity pattern, and randomized to receive either CIMT or Bimanual training, each of which were provided in a day-camp setting (90 h). Hand function was tested before, immediately and 6 months after the intervention with the Jebsen-Taylor Test of Hand Function, the Assisting Hand Assessment, the Box and Block Test, and ABILHAND-Kids. The Canadian Occupational Performance Measure was used to track goal achievement and the Pediatric Evaluation of Disability Inventory was used to assess functioning in daily living activities at home. Results: In contrast to our hypothesis, participants had statistically similar improvements for both CIMT and Bimanual training for all measures independent of their CST connectivity pattern (contralateral, ipsilateral, or bilateral) (p < 0.05 in all cases). Conclusions/Significance: The efficacy of CIMT and Bimanual training is independent of CST connectivity pattern. Children with an ipsilateral CST, previously thought to be maladaptive, have the capacity to improve as well as children with a contralateral or bilateral CST following intensive CIMT or Bimanual training. |
| Asunto: | Hemiplegia Reabilitação Extremidades Plasticidade Neuronal Modalidades de Fisioterapia |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | EEF - DEPARTAMENTO DE TERAPIA OCUPACIONAL EEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONAL |
| Tipo de acceso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.3389/fneur.2021.660780 |
| URI: | http://hdl.handle.net/1843/65215 |
| Fecha del documento: | 2-may-2021 |
| metadata.dc.url.externa: | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.660780/full |
| metadata.dc.relation.ispartof: | Frontiers in Neurology |
| Aparece en las colecciones: | Artigo de Periódico |
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