Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/65666| Type: | Artigo de Periódico |
| Title: | Effect of 3-UTR RET variants on RET mRNA secondary structure and disease presentation in medullary thyroid carcinoma |
| Authors: | Lucieli Ceolin Gerald Weber Ana Luiza Silva Maia Mírian Romitti Débora Rodrigues Siqueira Carla Vaz Ferreira Vargas Jessica Oliboni Scapineli Beatriz Maria de Azevedo Assis Brasil Rodolfo Vieira Maximiano Tauanne Dias Amarante Míriam Celi de Souza Nunes |
| Abstract: | The RET S836S variant has been associated with early onset and increased risk for metastatic disease in medullary thyroid carcinoma (MTC). However, the mechanism by which this variant modulates MTC pathogenesis is still open to discuss. Of interest, strong linkage disequilibrium (LD) between RET S836S and 3'UTR variants has been reported in Hirschsprung's disease patients. |
| Subject: | Câncer Ácido ribonucleico |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1371/journal.pone.0147840 |
| URI: | http://hdl.handle.net/1843/65666 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147840 |
| metadata.dc.relation.ispartof: | PLOS ONE |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Effect of 3UTR RET Variants on RET mRNA.pdf | 542.65 kB | Adobe PDF | View/Open |
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