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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/66055
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dc.creatorHenrique de Assis Lopes Ribeiropt_BR
dc.creatorTatiani Uceli Maiolipt_BR
dc.creatorLeandro Martins de Freitaspt_BR
dc.creatorPaolo Tieript_BR
dc.creatorFilippo Castiglionept_BR
dc.date.accessioned2024-03-19T14:28:27Z-
dc.date.available2024-03-19T14:28:27Z-
dc.date.issued2017-07-20-
dc.citation.volume7pt_BR
dc.citation.issue309pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.3389/fcimb.2017.00309pt_BR
dc.identifier.issn2235-2988pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/66055-
dc.description.resumoInfection by Leishmania protozoan parasites can cause a variety of disease outcomes in humans and other mammals, from single self-healing cutaneous lesions to a visceral dissemination of the parasite. The correlation between chronic lesions and ecto-nucleotidase enzymes activity on the surface of the parasite is addressed here using damage caused in epithelial cells by nitric oxide. In order to explore the role of purinergic metabolism in lesion formation and the outcome of the infection, we implemented a cellular automata/lattice gas model involving major immune characters (Th1 and Th2 cells, IFN-γ, IL-4, IL-12, adenosine−Ado−, NO) and parasite players for the dynamic analysis of the disease progress. The model were analyzed using partial ranking correlation coefficient (PRCC) to indicate the components that most influence the disease progression. Results show that low Ado inhibition rate over Th-cells is shared by L. major and L. braziliensis, while in L. amazonensis infection the Ado inhibition rate over Th-cells reaches 30%. IL-4 inhibition rate over Th-cell priming to Th1 independent of IL-12 are exclusive of L. major. The lesion size and progression showed agreement with published biological data and the model was able to simulate cutaneous leishmaniasis outcomes. The sensitivity analysis suggested that Ado inhibition rate over Th-cells followed by Leishmania survival probability were the most important characteristics of the process, with PRCC of 0.89 and 0.77 respectively. The simulations also showed a non-linear relationship between Ado inhibition rate over Th-cells and lesion size measured as number of dead epithelial cells. In conclusion, this model can be a useful tool for the quantitative understanding of the immune response in leishmaniasis.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEMpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Celular and Infection Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLeishmaniasispt_BR
dc.subjectCutaneouspt_BR
dc.subjectAdenosine (Ado)pt_BR
dc.subjectModelpt_BR
dc.subjectLattice-gaspt_BR
dc.subjectInflammationpt_BR
dc.subject.otherLeishmaniosept_BR
dc.subject.otherAdenosinapt_BR
dc.subject.otherInflamaçãopt_BR
dc.titleModeling Immune Response to Leishmania Species Indicates Adenosine As an Important Inhibitor of Th-Cell Activationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fcimb.2017.00309/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7538-3208pt_BR
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