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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/66223
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dc.creatorGabriela Silveira-Nunespt_BR
dc.creatorAndrea Teixeira-Carvalhopt_BR
dc.creatorClaudio Franceschipt_BR
dc.creatorSimone Rampellipt_BR
dc.creatorSilvia Turronipt_BR
dc.creatorPatrizia Brigidipt_BR
dc.creatorAna Maria Caetano Fariapt_BR
dc.creatorDanielle Fernandes Dursopt_BR
dc.creatorLuiz Roberto Alves de Oliveira Jr.pt_BR
dc.creatorEloisa Helena Medeiros Cunhapt_BR
dc.creatorTatiani Uceli Maiolipt_BR
dc.creatorAngelica Thomaz Vieirapt_BR
dc.creatorElaine Spezialipt_BR
dc.creatorRodrigo Corrêa-oliveirapt_BR
dc.creatorOlindo Assis Martins-filhopt_BR
dc.date.accessioned2024-03-20T20:12:57Z-
dc.date.available2024-03-20T20:12:57Z-
dc.date.issued2020-03-11-
dc.citation.volume11pt_BR
dc.citation.spage258pt_BR
dc.citation.epage14pt_BR
dc.identifier.doihttps://doi.org/10.3389/fphar.2020.00258pt_BR
dc.identifier.issn1663-9812pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/66223-
dc.description.resumoHypertension is a major global health challenge, as it represents the main risk factor for stroke and cardiovascular disease. It is a multifactorial clinical condition characterized by high and sustained levels of blood pressure, likely resulting from a complex interplay of endogenous and environmental factors. The gut microbiota has been strongly supposed to be involved but its role in hypertension is still poorly understood. In an attempt to fill this gap, here we characterized the microbial composition of fecal samples from 48 hypertensive and 32 normotensive Brazilian individuals by next-generation sequencing of the 16S rRNA gene. In addition, the cytokine production of peripheral blood samples was investigated to build an immunological profile of these individuals. We identified a dysbiosis of the intestinal microbiota in hypertensive subjects, featured by reduced biodiversity and distinct bacterial signatures compared with the normotensive counterpart. Along with a reduction in Bacteroidetes members, hypertensive individuals were indeed mainly characterized by increased proportions of Lactobacillus and Akkermansia while decreased relative abundances of well-known butyrate-producing commensals, including Roseburia and Faecalibacterium within the Lachnospiraceae and Ruminococcaceae families. We also observed an inflamed immune profile in hypertensive individuals with an increase in TNF/IFN-γ ratio, and in TNF and IL-6 production when compared to normotensive ones. Our work provides the first evidence of association of hypertension with altered gut microbiota and inflammation in a Brazilian population. While lending support to the existence of potential microbial signatures of hypertension, likely to be robust to age and geography, our findings point to largely neglected bacteria as potential contributors to intestinal homeostasis loss and emphasize the high vulnerability of hypertensive individuals to inflammation-related disorders.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEMpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Pharmacologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectGut microbiotapt_BR
dc.subjectDysbiosispt_BR
dc.subjectHypertensionpt_BR
dc.subjectInflammationpt_BR
dc.subjectImmune profilept_BR
dc.subject.otherMicrobiotapt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherHipertensãopt_BR
dc.subject.otherImunidadept_BR
dc.titleHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Populationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00258/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7538-3208pt_BR
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