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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/66225
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dc.creatorNatália Pinheiro Rosapt_BR
dc.creatorLícia Torrespt_BR
dc.creatorMariana de Almeida Oliveirapt_BR
dc.creatorMarcos Felipe Andrade-oliveirapt_BR
dc.creatorMauro Andrade de Freitas Guimarãespt_BR
dc.creatorMonique Macedo Coelhopt_BR
dc.creatorJuliana de Lima Alvespt_BR
dc.creatorTatiani Uceli Maiolipt_BR
dc.creatorAna M. Caetano Fariapt_BR
dc.date.accessioned2024-03-20T20:14:11Z-
dc.date.available2024-03-20T20:14:11Z-
dc.date.issued2021-08-25-
dc.citation.volume1pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage21pt_BR
dc.identifier.doihttps://doi.org/10.1093/immadv/ltab017pt_BR
dc.identifier.issn2732-4303pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/66225-
dc.description.resumoOral tolerance is a physiological phenomenon described more than a century ago as a suppressive immune response to antigens that gain access to the body by the oral route. It is a robust and long-lasting event with local and systemic effects in which the generation of mucosally induced regulatory T cells (iTreg) plays an essential role. The idea of using oral tolerance to inhibit autoimmune and allergic diseases by oral administration of target antigens was an important development that was successfully tested in 1980s. Since then, several studies have shown that feeding specific antigens can be used to prevent and control chronic inflammatory diseases in both animal models and clinically. Therefore, oral tolerance can be classified as an antigen-specific form of oral immunotherapy (OIT). In the light of novel findings on mechanisms, sites of induction and factors affecting oral tolerance, this review will focus on specific characteristics of oral tolerance induction and how they impact in its therapeutic application.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEMpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofImmunotherapy Advancespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectOral tolerancept_BR
dc.subjectGut mucosapt_BR
dc.subjectOral immunotherapypt_BR
dc.subjectRegulatory T Cellspt_BR
dc.subject.otherImunologiapt_BR
dc.subject.otherImunoterapiapt_BR
dc.subject.otherMucosa bucalpt_BR
dc.subject.otherLinfócitos T Reguladorespt_BR
dc.titleOral tolerance as antigen-specific immunotherapypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academic.oup.com/immunotherapyadv/article/1/1/ltab017/6357638pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2048-0318pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0604-8510pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7538-3208pt_BR
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