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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/66979
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dc.creatorPatrícia Carlos Caldeirapt_BR
dc.creatorAndrea María López Sotopt_BR
dc.creatorMaria Cássia Ferreira de Aguiarpt_BR
dc.creatorCarolina de Castro Martinspt_BR
dc.date.accessioned2024-04-09T18:34:53Z-
dc.date.available2024-04-09T18:34:53Z-
dc.date.issued2020-10-
dc.citation.volume26pt_BR
dc.citation.issue7pt_BR
dc.citation.spage1357pt_BR
dc.citation.epage1365pt_BR
dc.identifier.doihttps://doi.org/10.1111/odi.13194pt_BR
dc.identifier.issn1601-0825pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/66979-
dc.description.resumoObjectives: To assess the prognosis for early-stage oral squamous cell carcinoma according to tumor depth of invasion (DOI). Methods: This study was logged in the PROSPERO database under protocol # CRD42017059976. The search was conducted in six electronic databases up to May 2019. Fixed-effects meta-analysis was performed for the calculation of the odds ratio (OR) and respective 95% CI. Primary outcomes were lymph node metastasis, recurrence, and survival. Heterogeneity was calculated by the I2 test. The certainty of evidence was assessed by Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results: Twenty-seven studies were included (19 in the meta-analysis) with 2,404 patients with a mean of 60 years of age. High tumor DOI is associated with a greater chance of presenting lymph node metastasis, regardless of the cutoff point for DOI (13 meta-analysis; OR 1.69–53.08), recurrence (five meta-analysis; OR 1.22–3.83), and lower chance of survival (1 meta-analysis; OR 0.49). The certainty of evidence varied from very low to low. Conclusions: Tumor DOI is a good prognosticator for early-stage OSCC. The findings of the current meta-analysis highlight the clinical relevance of DOI and corroborate its incorporation for staging OSCC.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Diseases-
dc.rightsAcesso Restritopt_BR
dc.subjectLymph nodept_BR
dc.subjectMeta‐analysispt_BR
dc.subjectOral cancerpt_BR
dc.subjectPrognosispt_BR
dc.subjectSquamous cell carcinomapt_BR
dc.subject.otherLymph nodespt_BR
dc.subject.otherMeta-analysispt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherPrognosispt_BR
dc.subject.otherCarcinoma, squamous cellpt_BR
dc.titleTumor depth of invasion and prognosis of early-stage oral squamous cell carcinoma: a meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.13194pt_BR
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