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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/67131
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dc.creatorIves Charlie-Silvapt_BR
dc.creatorAndré Luis Branco de Barrospt_BR
dc.creatorJosé Dias Corrêa Juniorpt_BR
dc.creatorGustavo Batista de Menezespt_BR
dc.creatorHirla Costa Silva Fukushimapt_BR
dc.creatorTássia Flávia Dias Castropt_BR
dc.creatorRicardo Carneiro Borrapt_BR
dc.creatorFelipe Pierezanpt_BR
dc.creatorNathalie Ferreira Silva de Melopt_BR
dc.creatorLeonardo Fernandes Fracetopt_BR
dc.creatorNatália Martins Feitosapt_BR
dc.creatorJuliana Moreira Mendonça Gomespt_BR
dc.creatorDaniela Chemim de Melo Hoyospt_BR
dc.creatorCristiano Campos Mattiolipt_BR
dc.creatorSilas Fernandes Etopt_BR
dc.creatorDayanne Carla Fernandespt_BR
dc.creatorMarco Antonio de Andrade Belopt_BR
dc.creatorJuliana de Oliveira Silvapt_BR
dc.date.accessioned2024-04-12T20:12:27Z-
dc.date.available2024-04-12T20:12:27Z-
dc.date.issued2020-09-24-
dc.citation.volume15pt_BR
dc.citation.issue9pt_BR
dc.citation.spagee0238823pt_BR
dc.citation.epage17pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0238823pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/67131-
dc.description.resumoMucoadhesive polymeric nanocapsules have attracted interest of researchers from different fields from natural sciences because of their ability to interact with the mucosa and increase drug permeation. Anesthesia by immersion causes absorption through the skin and gills of fish, so it is important to evaluate the exposure of these organs to drug nanosystems. Benzocaine (BENZ) is one of the most popular anesthetic agents used in fish anesthesia, but it has drawbacks because of its low bioavailability, resulting in weak absorption after immersion. Here we describe method developed for preparing and characterizing chitosan-coated PLGA mucoadhesive nanoparticles containing BENZ (NPMAs) for zebrafish immersion anesthesia. We determined the lowest effective concentration, characterized the interaction of the mucoadhesive system with fish, measured the anesthetic efficacy, and evaluated possible toxic effects in embryos and adults exposed to the nanoformulations. This study opens perspectives for using nanoformulations prepared with BENZ in aquaculture, allowing reduction of dosage as well as promoting more effective anesthesia and improved interaction with the mucoadhesive system of fish.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFARMACIA - FACULDADE DE FARMACIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIApt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE ZOOTECNIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPlos Onept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMucosapt_BR
dc.subjectNanocápsulaspt_BR
dc.subjectPreparações Farmacêuticaspt_BR
dc.subjectToxicologiapt_BR
dc.subjectPeixe-Zebrapt_BR
dc.subject.otherMucosapt_BR
dc.subject.otherNanocápsulaspt_BR
dc.subject.otherPreparações Farmacêuticaspt_BR
dc.subject.otherToxicologiapt_BR
dc.subject.otherPeixe-Zebrapt_BR
dc.titlePotential of mucoadhesive nanocapsules in drug release and toxicology in zebrafishpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238823pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-7572-2767pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-8623-8524pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6196-2404pt_BR
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