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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/67137
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dc.creatorMaria Luíza R. P. Limapt_BR
dc.creatorLaura H. R. Leitept_BR
dc.creatorCarolina R. Giodapt_BR
dc.creatorFabiola de Oliveira Paes Lemept_BR
dc.creatorClaudia A. Coutopt_BR
dc.creatorCândido C. Coimbrapt_BR
dc.creatorVirginia H. R. Leitept_BR
dc.creatorTeresa Cristina A. Ferraript_BR
dc.date.accessioned2024-04-12T20:15:00Z-
dc.date.available2024-04-12T20:15:00Z-
dc.date.issued2016-
dc.citation.volume2016pt_BR
dc.identifier.doihttps://doi.org/10.1155/2016/9127076pt_BR
dc.identifier.issn2314-6753pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/67137-
dc.description.resumoThe pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and experimental models are an alternative to study this issue. We investigated the effects of a simple carbohydrate-rich diet on the development of obesity-related NAFLD and the impact of physical training on the metabolic abnormalities associated with this disorder. Sixty Wistar rats were randomly separated into experimental and control groups, which were fed with sucrose-enriched (18% simple carbohydrates) and standard diet, respectively. At the end of each experimental period (5, 10, 20, and 30 weeks), 6 animals from each group were sacrificed for blood tests and liver histology and immunohistochemistry. From weeks 25 to 30, 6 animals from each group underwent physical training. The experimental group animals developed obesity and NAFLD, characterized histopathologically by steatosis and hepatocellular ballooning, clinically by increased thoracic circumference and body mass index associated with hyperleptinemia, and metabolically by hyperglycemia, hyperinsulinemia, hypertriglyceridemia, increased levels of very low-density lipoprotein- (VLDL-) cholesterol, depletion of the antioxidants liver enzymes superoxide dismutase and catalase, and increased hepatic levels of malondialdehyde, an oxidative stress marker. Rats that underwent physical training showed increased high-density lipoprotein- (HDL-) cholesterol levels. In conclusion, a sucrose-rich diet induced obesity, insulin resistance, oxidative stress, and NAFLD in rats.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Diabetes Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectWistar Ratpt_BR
dc.subjectNonalcoholic fatty liver diseasept_BR
dc.subjectSucrose-rich dietpt_BR
dc.subjectObesitypt_BR
dc.subject.otherRatos Wistarpt_BR
dc.subject.otherHepatopatia gordurosa não alcoólicapt_BR
dc.subject.otherSacarose na dietapt_BR
dc.subject.otherObesidadept_BR
dc.titleA novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich dietpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.hindawi.com/journals/jdr/2016/9127076/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4013-0147pt_BR
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