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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/67449
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Campo DCValorIdioma
dc.creatorNívea Pereira de Sápt_BR
dc.creatorCaroline Miranda de Limapt_BR
dc.creatorCleudiomar Inácio Linopt_BR
dc.creatorPaulo Jorge Sanches Barbeirapt_BR
dc.creatorLudmila de Matos Baltazarpt_BR
dc.creatorDaniel Assis Santospt_BR
dc.creatorRenata Barbosa de Oliveirapt_BR
dc.creatorEleftherios Mylonakispt_BR
dc.creatorBeth Burgwyn Fuchspt_BR
dc.creatorSusana Johannpt_BR
dc.date.accessioned2024-04-19T12:09:05Z-
dc.date.available2024-04-19T12:09:05Z-
dc.date.issued2017-
dc.citation.volume61pt_BR
dc.citation.issue8pt_BR
dc.identifier.doihttps://doi.org/10.1128/aac.02700-16pt_BR
dc.identifier.issn1098-6596pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/67449-
dc.description.resumoHuman cryptococcosis can occur as a primary or opportunistic infection and develops as an acute, subacute, or chronic systemic infection involving different organs of the host. Given the limited therapeutic options and the occasional resistance to fluconazole, there is a need to develop novel drugs for the treatment of cryptococcosis. In this report, we describe promising thiazole compounds 1, 2, 3, and 4 and explore their possible modes of action against Cryptococcus. To this end, we show evidence of interference in the Cryptococcus antioxidant system. The tested compounds exhibited MICs ranging from 0.25 to 2 μg/ml against Cryptococcus neoformans strains H99 and KN99α. Interestingly, the knockout strains for Cu oxidase and sarcosine oxidase were resistant to thiazoles. MIC values of thiazole compounds 1, 2, and 4 against these mutants were higher than for the parental strain. After the treatment of C. Neoformans ATCC 24067 (or C. deneoformans) and C. Gattii strain L27/01 (or C. deuterogattii) with thiazoles, we verified an increase in intracellular reactive oxygen species (ROS). Also, we verified the synergistic interactions among thiazoles and menadione, which generates superoxides, with fractional inhibitory concentrations (FICs) equal to 0.1874, 0.3024, 0.25, and 0.25 for the thiazole compounds 1, 2, 3, and 4, respectively. In addition, thiazoles exhibited antagonistic interactions with parasulphonatephenyl porphyrinato ferrate III (FeTPPS). Thus, in this work, we showed that the action of these thiazoles is related to an interference with the antioxidant system. These findings suggest that oxidative stress may be primarily related to the accumulation of superoxide radicals.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAntimicrobial Agents and Chemotherapypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAntifungalpt_BR
dc.subjectAntioxidantpt_BR
dc.subjectCryptococcuspt_BR
dc.subjectThiazolespt_BR
dc.subjectROSpt_BR
dc.subjectRNSpt_BR
dc.subject.otherAntimicoticospt_BR
dc.subject.otherFungospt_BR
dc.subject.otherCompostos heterociclicospt_BR
dc.subject.otherAtividade antifúngicapt_BR
dc.subject.otherTremellalespt_BR
dc.subject.otherMicoses sistêmicaspt_BR
dc.titleHeterocycle thiazole compounds exhibit antifungal activity through increase in the production of reactive oxygen species in Cryptococcus neoformans-Cryptococcus gatti species complexpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.asm.org/doi/10.1128/aac.02700-16pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0770-8680pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4255-3047pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1108-5666pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5884-2567pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4624-0777pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8068-1720pt_BR
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