Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/67847
Tipo: Artigo de Periódico
Título: Effects of high-dose bisphenol a on the mouse oral mucosa: a possible link with oral cancers
Autor(es): Tatiana Fernandes Araujo Almeida
Sicília Rezende Oliveira
Janine Mayra da Silva
Ana Laura Fernandes de Oliveira
Zenilda de Lourdes Cardeal
Helvécio Costa Menezes
José Messias Gomes
Gabriel Henrique Campolina silva
Cleida Aparecida Oliveira
Soraia Macari
Gustavo Pompermaier Garlet
Ivana Márcia Alves Diniz
Andréia Machado Leopoldino
Tarcília Aparecida Silva
Resumo: Bisphenol A (BPA) is an endocrine disrupting chemical able to promote hormone-responsive tumors. The major route of BPA contamination being oral, the aim of the present study was to investigate BPA effects on oral cells. Here, we evaluated the impact of sub-chronic in vivo exposure to BPA and its in vitro effects on neoplastic and non-neoplastic oral cells. We evaluated the oral mucosa of mice chronically exposed to BPA (200 mg/L). The response of keratinocytes (NOK–SI) and Head and Neck (HN) Squamous Cell Carcinoma (SCC), HN12 and HN13 cell lines to BPA was examined. In vivo, BPA accumulated in oral tissues and caused an increase in epithelial proliferative activity. BPA disrupted the function of keratinocytes by altering pro-survival and proliferative pathways and the secretion of cytokines and growth factors. In tumor cells, BPA induced proliferative, invasive, pro-angiogenic, and epigenetic paths. Our data highlight the harmful effects of BPA on oral mucosa and, tumorigenic and non-tumorigenic cells. Additionally, BPA may be a modifier of oral cancer cell behavior by prompting a functional shift to a more aggressive phenotype.
Assunto: Celulas - Cultura e meios de cultura.
Tumores
Estrogenos
Idioma: eng
País: Brasil
Editor: Universidade Federal de Minas Gerais
Sigla da Instituição: UFMG
Departamento: FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
ICB - DEPARTAMENTO DE MORFOLOGIA
ICX - DEPARTAMENTO DE QUÍMICA
Tipo de Acesso: Acesso Restrito
Identificador DOI: https://doi.org/10.1016/j.envpol.2021.117296
URI: http://hdl.handle.net/1843/67847
Data do documento: 2021
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/pii/S0269749121008782
metadata.dc.relation.ispartof: Environmental Pollution
Aparece nas coleções:Artigo de Periódico

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