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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/67888
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dc.creatorParth Patelpt_BR
dc.creatorPayal Patelpt_BR
dc.creatorMeha Bhattpt_BR
dc.creatorCody Braunpt_BR
dc.creatorHousne Begumpt_BR
dc.creatorRobby Nieuwlaatpt_BR
dc.creatorRasha Khatibpt_BR
dc.creatorCarolina de Castro Martinspt_BR
dc.creatorYuan Zhangpt_BR
dc.creatorItziar Etxeandia-Ikobaltzetapt_BR
dc.creatorJamie Varghesept_BR
dc.creatorHani Alturkmanipt_BR
dc.creatorWaled Bahajpt_BR
dc.creatorMariam Baigpt_BR
dc.creatorRohan Keharpt_BR
dc.creatorAhmad Mustafapt_BR
dc.creatorRakesh Ponnapureddypt_BR
dc.creatorAnchal Sethipt_BR
dc.creatorMerrill Thomaspt_BR
dc.creatorDavid Wooldridgept_BR
dc.creatorWendy Limpt_BR
dc.creatorShannon Batespt_BR
dc.creatorEddy Langpt_BR
dc.creatorGrégoire Le Galpt_BR
dc.creatorLinda Haramatipt_BR
dc.creatorJeffrey Klinept_BR
dc.creatorMarc Righinipt_BR
dc.creatorWojtek Wierciochpt_BR
dc.creatorHolger Schunemannpt_BR
dc.creatorReem Mustafapt_BR
dc.date.accessioned2024-04-29T20:09:00Z-
dc.date.available2024-04-29T20:09:00Z-
dc.date.issued2021-04-
dc.citation.volume5pt_BR
dc.citation.issue8pt_BR
dc.citation.spage2237pt_BR
dc.citation.epage2244pt_BR
dc.identifier.doihttps://doi.org/10.1182/bloodadvances.2020002398pt_BR
dc.identifier.issn2473-9537pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/67888-
dc.description.resumoPrompt evaluation and therapeutic intervention of suspected pulmonary embolism (PE) are of paramount importance for improvement in outcomes. We systematically reviewed outcomes in patients with suspected PE, including mortality, incidence of recurrent PE, major bleeding, intracranial hemorrhage, and postthrombotic sequelae. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for eligible studies, reference lists of relevant reviews, registered trials, and relevant conference proceedings. We included 22 studies with 15 865 patients. Among patients who were diagnosed with PE and discharged with anticoagulation, 3-month follow-up revealed that all-cause mortality was 5.69% (91/1599; 95% confidence interval [CI], 4.56-6.83), mortality from PE was 1.19% (19/1597; 95% CI, 0.66-1.72), recurrent venous thromboembolism (VTE) occurred in 1.38% (22/1597; 95% CI: 0.81-1.95), and major bleeding occurred in 0.90% (2/221%; 95% CI, 0-2.15). In patients with a low pretest probability (PTP) and negative D-dimer, 3-month follow-up revealed mortality from PE was 0% (0/808) and incidence of VTE was 0.37% (4/1094; 95% CI: 0.007-0.72). In patients with intermediate PTP and negative D-dimer, 3-month follow-up revealed that mortality from PE was 0% (0/2747) and incidence of VTE was 0.46% (14/3015; 95% CI: 0.22-0.71). In patients with high PTP and negative computed tomography (CT) scan, 3-month follow-up revealed mortality from PE was 0% (0/651) and incidence of VTE was 0.84% (11/1302; 95% CI: 0.35-1.34). We further summarize outcomes evaluated by various diagnostic tests and diagnostic pathways (ie, D-dimer followed by CT scan).pt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBlood Advances-
dc.rightsAcesso Restritopt_BR
dc.subjectAnticoagulationpt_BR
dc.subjectFibrin fragment d substancept_BR
dc.subjectFollow-uppt_BR
dc.subjectHemorrhagept_BR
dc.subjectPulmonary embolismpt_BR
dc.subjectVenous thromboembolismpt_BR
dc.subjectIntracranial hemorrhagespt_BR
dc.subjectComputed tomographypt_BR
dc.subjectTherapeutic interventionpt_BR
dc.subjectEmbasept_BR
dc.subject.otherAnticoagulantspt_BR
dc.subject.otherHemorrhagept_BR
dc.subject.otherPulmonary embolismpt_BR
dc.subject.otherVenous thromboembolismpt_BR
dc.subject.otherIntracranial hemorrhagespt_BR
dc.subject.otherTomography, X-ray computedpt_BR
dc.subject.otherTherapeuticspt_BR
dc.titleSystematic review and meta-analysis of outcomes in patients with suspected pulmonary embolismpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://ashpublications.org/bloodadvances/article/5/8/2237/475796/Systematic-review-and-meta-analysis-of-outcomes-inpt_BR
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