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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/68003
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dc.creatorBernardo de Carvalho Dutrapt_BR
dc.creatorAlcione Maria Soares Dutra Oliveirapt_BR
dc.creatorPeterson Antônio Dutra Oliveirapt_BR
dc.creatorLuís Otávio de Miranda Cotapt_BR
dc.creatorJuliana Oliveira Silveirapt_BR
dc.creatorFernando de Oliveira Costapt_BR
dc.date.accessioned2024-04-30T18:52:42Z-
dc.date.available2024-04-30T18:52:42Z-
dc.date.issued2019-
dc.identifier.doihttps://doi.org/10.1002/JPER.19-0160pt_BR
dc.identifier.issn1943-3670pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/68003-
dc.description.resumoBackground Sodium alendronate (ALN) is an aminobisphosphonate and potent inhibitor of bone resorption. It has been suggested that ALN might be a promising carrier of biomolecules for periodontal bone repair. The aim of this randomized split-mouth clinical trial was to evaluate the effects of the topical application of 1% ALN gel in intrabony defects during the surgical treatment of patients with periodontitis. Methods Sixty-four intrabony defects from 32 patients with periodontitis were randomly treated with either 1% ALN gel or placebo gel during periodontal surgeries. Full-mouth periodontal examination was performed at baseline and at 3 and 6 months after surgical treatment. Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were recorded as the clinical outcomes. Bone defects were evaluated by digital subtraction radiography (DSR) at baseline and 6 months post-treatment. Analyses were performed through Fisher, Kruskal-Wallis, and ANOVA tests and a generalized estimation equations method. Results Both ALN and placebo groups showed significant improvements in BOP, PD, and CAL after periodontal surgical procedures (P < 0.001). Intergroup analysis showed significantly better outcomes in the ALN group with higher PD reduction and clinical attachment gain. DSR showed positive effects on periodontal bone repair strongly associated in the ALN group (P < 0.001). Conclusion Topical application of 1% ALN may be a promising and beneficial adjuvant for the treatment of intrabony defects during surgical periodontal therapy.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Periodontologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectalendronate sodium randomized clinical trialspt_BR
dc.subjectperiodontal surgicalpt_BR
dc.subjectacesso restrito busca dia 23/04/2024 fao clínica assunto:Alendronate periódico: Journal of periodontology Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month randomized controlled clinical trialpt_BR
dc.subjectKeywords: alendronate; bone regeneration; dental digital radiography; periodontitis.pt_BR
dc.subject.otherAlendronatept_BR
dc.subject.otherBone regenerationpt_BR
dc.subject.otherRadiography, dental, digitalpt_BR
dc.subject.otherPeriodontitispt_BR
dc.subject.otherOral surgical procedurespt_BR
dc.subject.otherBone and bonespt_BR
dc.titleEffects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month randomized controlled clinical trialpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://aap.onlinelibrary.wiley.com/doi/10.1002/JPER.19-0160pt_BR
dc.identifier.orcidspt_BR
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