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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/68066
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dc.creatorElisa Grillo Araújopt_BR
dc.creatorDomitilla Marchiori Sant’Anna Leal de Oliveirapt_BR
dc.creatorCarolina de Castro Martinspt_BR
dc.creatorCristine Miron Stefanpt_BR
dc.date.accessioned2024-05-02T22:24:11Z-
dc.date.available2024-05-02T22:24:11Z-
dc.date.issued2022-03-
dc.citation.volume11pt_BR
dc.citation.issue4pt_BR
dc.citation.spage621pt_BR
dc.identifier.doihttps://doi.org/10.3390/antiox11040621pt_BR
dc.identifier.issn2076-3921pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/68066-
dc.description.resumoThis network meta-analysis (NMA) investigated the effectiveness of antioxidants as adjuncts to non-surgical periodontal therapy (NSPT) in the glycated hemoglobin (HbA1c) control of type 2 diabetes (T2D) patients with periodontitis. PubMed, Cochrane, LILACS, Web of Science, Scopus, Embase, LIVIVO, and grey literature were searched. Risk of bias was assessed with the RoB v2.0 tool. A frequentist NMA assessed HbA1c improvement, through standardized mean difference under a random-effects model. Certainty of evidence was addressed through the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) partially contextualized framework. Ten randomized controlled clinical trials were included, with 234 patients receiving alpha lipoic acid (ALA), cranberry juice, cranberry juice enriched with omega-3, fenugreek, ginger, grape seed, lycopene, melatonin, omega-3, propolis or vitamin C supplementation to NSPT, and 220 patients receiving NSPT alone or with placebo. Nine studies were meta-analyzed. HbA1c improved when NSPT was combined with propolis, ALA and melatonin supplementation (moderate-to-low certainty), compared to NSPT alone or with placebo. Risk of bias issues were found in eight studies. In conclusion, the use of propolis supplementation to NSPT probably results in HbA1c improvement in T2D patients with periodontitis (large effect with moderate certainty), while ALA and melatonin supplementation may contribute to reduce the HbA1c in T2D patients with periodontitis (large effects with low certainty).pt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAntioxidants-
dc.rightsAcesso Abertopt_BR
dc.subjectAntioxidantspt_BR
dc.subjectType 2 diabetes mellituspt_BR
dc.subjectNon-surgical periodontal therapypt_BR
dc.subject.otherAntioxidantspt_BR
dc.subject.otherDiabetes mellitus, type 2pt_BR
dc.subject.otherPeriodontitispt_BR
dc.subject.otherPeriodontal debridementpt_BR
dc.subject.otherNetwork meta-analysispt_BR
dc.titleEfficacy of antioxidant supplementation to non-surgical periodontal therapy on metabolic control in type 2 diabetes patients: a network meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/2076-3921/11/4/621pt_BR
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