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http://hdl.handle.net/1843/68752| Type: | Artigo de Periódico |
| Title: | Gingival crevicular fluid levels of human beta-defensin 1 in individuals with and without chronic periodontitis |
| Authors: | Lidiane Cristina Machado Costa Daniela Leal Zandim-Barcelos Jose Eustaquio da Costa Fernando de Oliveira Costa Luis Otávio de Miranda Cota Soldati Fonseca Abreu |
| Abstract: | Background and objective: Human beta-defensins (hBDs) contribute to innate immunity antimicrobial activity. They are also effective in the adaptive immune response and may play a crucial role in the susceptibility to diseases of the oral cavity. This study aimed to evaluate the levels of hBD-1 in the gingival crevicular fluid of individuals with and without chronic periodontitis. Material and methods: Twenty periodontally healthy individuals (H) and 20 individuals with chronic periodontitis were recruited. Gingival crevicular fluid samples were collected from: healthy sites (Hh) from periodontally healthy individuals; and healthy sites (Ph), sites with gingivitis (Pg), and sites with periodontitis (Pp) from individuals with periodontitis. The levels of hBD-1 (pg/mL) were measured using enzyme-linked immunosorbent assay. Comparisons of hBD-1 between individuals (H and chronic periodontitis) and among sites (Hh, Ph, Pg, Pp) were performed through hierarchical linear modeling. Results: Gingival crevicular fluid levels of hBD-1 were: Hh = 229.52 ± 138.96 (median 199.26), Ph = 53.88 ± 58.17 (median 35.75), Pg = 57.11 ± 40.18 (median 39.90) and Pp = 55.31 ± 37.28 (median 54.19). No influence of site diagnosis (level 1; health/gingivitis/periodontitis) was observed; however, individual diagnosis (level 2; health/periodontitis) influenced the levels of hBD-1 (P < .001). Conclusion: Periodontally healthy individuals showed higher gingival crevicular fluid levels of hBD-1 when compared to individuals with chronic periodontitis. This suggests a potential protective role of hBD-1 in the susceptibility to chronic periodontitis. |
| Subject: | Enzyme-Linked Immunosorbent Assay Beta-defensins Chronic periodontitis Gingival crevicular fluid Gingiva Gingivitis |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA FAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA FAO - FACULDADE DE ODONTOLOGIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/jre.12558 |
| URI: | http://hdl.handle.net/1843/68752 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jre.12558 |
| metadata.dc.relation.ispartof: | Journal of Periodontal Research |
| Appears in Collections: | Artigo de Periódico |
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