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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/68769
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dc.creatorVanessa Buerispt_BR
dc.creatorFábio P. Sellerapt_BR
dc.creatorBruna Fugapt_BR
dc.creatorElder Sanopt_BR
dc.creatorMarcelo Pires Nogueira de Carvalhopt_BR
dc.creatorSamuel Campanelli Freitas Coutopt_BR
dc.creatorQuezia Mourapt_BR
dc.creatorNilton Lincopanpt_BR
dc.date.accessioned2024-05-29T18:15:43Z-
dc.date.available2024-05-29T18:15:43Z-
dc.date.issued2022-
dc.citation.volume12pt_BR
dc.identifier.doihttp://dx.doi.org/10.1038/s41598-022-09598-8pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/68769-
dc.description.resumoThe global spread of critical-priority antimicrobial-resistant Enterobacterales by food is a public health problem. Wild-caught seafood are broadly consumed worldwide, but exposure to land-based pollution can favor their contamination by clinically relevant antimicrobial-resistant bacteria. As part of the Grand Challenges Explorations: New Approaches to Characterize the Global Burden of Antimicrobial Resistance Program, we performed genomic surveillance and cell culture-based virulence investigation of WHO critical priority Enterobacterales isolated from marine bivalves collected in the Atlantic Coast of South America. Broad-spectrum cephalosporin-resistant Klebsiella pneumoniae and Escherichia coli isolates were recovered from eight distinct geographical locations. These strains harbored blaCTX-M-type or blaCMY-type genes. Most of the surveyed genomes confirmed the convergence of wide virulome and resistome (i.e., antimicrobials, heavy metals, biocides, and pesticides resistance). We identified strains belonging to the international high-risk clones K. pneumoniae ST307 and E. coli ST131 carrying important virulence genes, whereas in vitro experiments confirmed the high virulence potential of these strains. Thermolabile and thermostable toxins were identified in some strains, and all of them were biofilm producers. These data point to an alarming presence of resistance and virulence genes in marine environments, which may favor horizontal gene transfer and the spread of these traits to other bacterial species.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectEnterobacteralespt_BR
dc.subjectWHOpt_BR
dc.subjectMarine bivalvespt_BR
dc.subjectSeafoodpt_BR
dc.subject.otherEnterobacteriaceaept_BR
dc.subject.otherOrganização Mundial da Saúdept_BR
dc.subject.otherBivalvespt_BR
dc.subject.otherIntoxicação por frutos do marpt_BR
dc.titleConvergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalvespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/s41598-022-09598-8pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0210-8352pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3758-4148pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0161-5800pt_BR
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