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Type:	Artigo de Periódico
Title:	Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial
Authors:	Bernardo Carvalho Dutra Alcione Maria Soares Dutra de Oliveira Peterson Antonio Dutra de Oliveira Flávio Ricardo Manzi Sheila Cavalca Cortelli Luis Otávio de Miranda Cota Fernando de Oliveira Costa
Abstract:	Background and objectives: Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT). Material and methods: Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes. After manual scaling and root planing, 40 bilateral sites with interproximal vertical bone defects were randomly treated with either 1% ALN gel or a placebo. Bone defects were evaluated through CBCT at the baseline and 6 months post-treatment. The clinical and CBCT parameters were compared using the Wilcoxon and Friedman tests (p<0.05). Results: Although ALN produced a greater CAL gain when compared to the placebo at 6 months post-treatment (p=0.021), both treatments produced similar effects on the PPD, BOP, and bone height. Significant differences in bone fill were observed only in patients of the ALN group (4.5 to 3.8 mm; p=0.003) at 6 months post-treatment.
Subject:	Alendronate Sodium Periodontitis Dental scaling Bone and bones Cone-beam computed tomography
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE CLÍNICA
metadata.dc.identifier.doi:	https://doi.org/10.1590/1678-7757-2016-0252
URI:	http://hdl.handle.net/1843/68805
Issue Date:	2017
metadata.dc.url.externa:	https://www.scielo.br/j/jaos/a/FfxBKfPv8JkJx9QwdgSjdNh/?lang=en
metadata.dc.relation.ispartof:	Journal of Applied Oral Science
Appears in Collections:	Artigo de Periódico

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