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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/69081
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dc.creatorMaria Fernanda Gontijo Sepulvedafusaropt_BR
dc.creatorJovita Lane Soares Santos Zaninipt_BR
dc.creatorIvani Novato Silvapt_BR
dc.date.accessioned2024-06-11T14:47:53Z-
dc.date.available2024-06-11T14:47:53Z-
dc.date.issued2016-
dc.citation.volume8pt_BR
dc.citation.issue74pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1186/s13098-016-0190-0pt_BR
dc.identifier.issn1758-5996pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/69081-
dc.description.resumoBackground Increased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1). Objectives Evaluate CIMT and its association with cardiovascular risk factors in Brazilian adolescents with DM1. Methods Cross-sectional study of 118 adolescents, 57 with DM1 and no chronic complications related to the disease, and 61 healthy individuals. Clinical, biochemical, and high-resolution B-mode ultrasonographic evaluations according to the Consensus Statement of the American Society of Echocardiography CIMT Task Force were performed. Results Adolescents with diabetes (66.6% female) were 14.5 ± 2.9 years old and had 9.0 ± 4.0 years of disease duration. The healthy adolescents (62.3% female) were 14.3 ± 2.6 years old. All the adolescents had blood pressure within their reference ranges. In 66% of DM1 adolescents the systolic blood pressure was >50th percentile. Increased CIMT was observed in adolescents with diabetes compared with those in the control group: 0.53 vs 0.51 mm (p < 0.004) on the right side, and 0.55 vs 0.51 mm (p < 0.001) on the left side. CIMT presented independent and positive associations with diabetes duration, total cholesterol level, low-density lipoprotein cholesterol level, and systolic blood pressure percentile in DM1 adolescents. Conclusions Increased CIMT was observed in young Brazilian adolescents with DM1, and was associated with cardiovascular risk factors. CIMT assessment may be useful for the early identification and monitoring of cardiovascular risk in this age group.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEMpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofDiabetology & Metabolic Syndromept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDiabetes Mellituspt_BR
dc.subjectCarotid intima-media thicknesspt_BR
dc.subjectAtherosclerosis, Risk Factorspt_BR
dc.subjectUltrasonographypt_BR
dc.subject.otherDiabetes Mellituspt_BR
dc.subject.otherEspessura Intima-Media Carotídeapt_BR
dc.subject.otherAterosclerosept_BR
dc.subject.otherUltrassonografiapt_BR
dc.titleIncreased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellituspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://dmsjournal.biomedcentral.com/articles/10.1186/s13098-016-0190-0#rightslinkpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3585-4917pt_BR
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