Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/69128| Type: | Artigo de Periódico |
| Title: | Mast cell degranulation in periodontal disease from HIV-infected individuals |
| Authors: | Giovanna Ribeiro Souto Alessandro Oliveira de Jesus Takeshi Kato Segundo Paôlla Freitas Perdigão Fernando de Oliveira Costa Ricardo Alves de Mesquita |
| Abstract: | Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment. |
| Subject: | Mast cells Infections Inflammation Mouth mucosa Cell count Immune system HIV |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA FAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.20396/bjos.v18i0.8656600 |
| URI: | http://hdl.handle.net/1843/69128 |
| Issue Date: | 10-Sep-2019 |
| metadata.dc.url.externa: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8656600 |
| metadata.dc.relation.ispartof: | Brazilian Journal of Oral Sciences |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Mast cell degranulation in periodontal disease from HIV-infected individuals.pdf | 282.04 kB | Adobe PDF | View/Open |
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