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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/69182
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dc.creatorAna Carolina Bueno Silvapt_BR
dc.creatorLeni Marcia Anchietapt_BR
dc.creatorMarianna Fischer de Paula Lopespt_BR
dc.creatorRoberta Maia de Castro Romanellipt_BR
dc.date.accessioned2024-06-12T20:58:29Z-
dc.date.available2024-06-12T20:58:29Z-
dc.date.issued2018-08-18-
dc.citation.volume22pt_BR
dc.citation.issue4pt_BR
dc.citation.spage328pt_BR
dc.citation.epage337pt_BR
dc.identifier.doi10.1016/j.bjid.2018.07.009pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/69182-
dc.description.resumoBackground: Technologies and life support management have enhanced the survival of preterm infants. The immune system of newborns is immature, which contributes to the occurrence of healthcare-associated infections. The overlap of several conditions with neonatal sepsis and the difficulty of diagnosis and laboratory confirmation during this period result in a tendency to over-treat neonatal sepsis. The use of antimicrobial agents is a risk factor for multidrug-resistant bacterial infections. This work aimed to perform a systematic review of the relationship between inadequate use of antimicrobial agents and increase in neonatal sepsis related to healthcare assistance, due to bacterial resistance. Methods: Our population, exposition, comparison, outcome and study type was as follows: P: hospitalized neonates with sepsis diagnosis, E: inappropriate use of antimicrobial agents, C: adequate use of antimicrobial agents or no indication of infection, O: resistant bacterial infection, and S: original studies. We performed searches in the PubMed, Scopus, Virtual Health Library (Scielo, LILACS, and MEDLINE), and Embase without limits on time, language, and the references of the articles found. Fourteen studies were included and assessed using the Grading of Recommendations, Assessment, Development, and Evaluation, Newcastle, and the Strengthening the Reporting of Observacional Studies in Epidemiology methodologies. Results: All studies found were observational and started with a low-quality evidence level in the Grading of Recommendations, Assessment, Development, and Evaluation. Conclusions: Despite their low-quality evidence, the studies demonstrated the association between inadequate use of antimicrobial agents and increase of neonatal resistant bacterial healthcare-associated infections in neonatal units. However, there is significant difficulty in conducting high-quality studies in this population due to ethical issues tied to randomized trials. Therefore, new studies should be encouraged to recommend adequate treatment of newborns without increasing the risk of healthcare-associated infections by multidrug-resistant bacteria.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Infectious Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherSepse Neonatalpt_BR
dc.subject.otherResistência Microbiana a Medicamentospt_BR
dc.subject.otherRecém-Nascidopt_BR
dc.subject.otherAnti-Infecciosospt_BR
dc.titleInadequate use of antibiotics and increase in neonatal sepsis caused by resistant bacteria related to health care assistance: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bjid/a/XGzpHNhGBVHzTRgttCy4yPd/abstract/?lang=enpt_BR
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