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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/69366
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dc.creatorRafael Paschoal Esteves Limapt_BR
dc.creatorAndressa Rafaela Silva Atanaziopt_BR
dc.creatorFernando de Oliveira Costapt_BR
dc.creatorFabiano Araújo Cunhapt_BR
dc.creatorLucas Guimarães Abreupt_BR
dc.date.accessioned2024-06-24T17:57:19Z-
dc.date.available2024-06-24T17:57:19Z-
dc.date.issued2021-06-
dc.citation.volume21pt_BR
dc.citation.issue2pt_BR
dc.citation.spage101546pt_BR
dc.citation.epageJournal of Evidence Based Dental Practicept_BR
dc.identifier.doihttps://doi.org/10.1016/j.jebdp.2021.101546pt_BR
dc.identifier.issn1532-3390pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/69366-
dc.description.resumoObjective The objective of this systematic review and meta-analysis was to search for scientific evidence on the impact of non-surgical periodontal therapy on tumor necrosis factor alpha (TNF-α) in type 2 diabetics. Methods The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement has been followed. The study was registered (CRD42020192790) in the International prospective register of systematic reviews. Searches were conducted in five databases. Restrictions on publication date were not imposed in anyway. The studies reporting the serum TNF-α levels of individuals with type 2 diabetes mellitus (DM) before and after non-surgical periodontal therapy were included. Studies’ selection, extraction of data and risk of bias assessment were performed in duplicate. Consensus was achieved. Meta‐analysis was carried out. The 95% confidence interval and odds ratio were provided. Results Six hundred and twenty-three references were retrieved and eighteen studies were included. Meta-analysis demonstrated that the serum levels of TNF-α in individuals with type 2 DM decreased six months after non-surgical periodontal therapy (mean difference = -1.90, confidence interval = -3.05–-0.74). Included studies presented low risk of bias. Conclusion Non-surgical periodontal therapy has an impact on serum TNF-α levels at six months in type 2 DM patients.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Evidence Based Dental Practicept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectrevisão sistemática acesso restrito fao clínica e fao odontopediatria busca dia 21/06/2024Impact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysispt_BR
dc.subjectTNF- alfa key words Diabetes mellitus, Type 2 Tumor necrosis factor-alpha Periodontitispt_BR
dc.subjectdiabetes type 2pt_BR
dc.subjectperiodontal treatment Journal of Evidence Based Dental Practicept_BR
dc.subject.otherDiabetes Mellitus, Type 2pt_BR
dc.subject.otherPeriodontitispt_BR
dc.subject.otherTumor necrosis factor-alphapt_BR
dc.subject.otherTherapeuticspt_BR
dc.subject.otherNetwork meta-analysispt_BR
dc.subject.otherSystematic reviewpt_BR
dc.titleImpact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S153233822100021Xpt_BR
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