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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/70454
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dc.creatorBianca Menezes Diaspt_BR
dc.creatorFabiana Silvestre dos Santospt_BR
dc.creatorAdriano Max Moreira Reispt_BR
dc.date.accessioned2024-07-12T18:01:48Z-
dc.date.available2024-07-12T18:01:48Z-
dc.date.issued2019-08-
dc.citation.volume137pt_BR
dc.citation.issue4pt_BR
dc.citation.spage369pt_BR
dc.citation.epage378pt_BR
dc.identifier.doihttps://doi.org/10.1590/1516-3180.2019.013405072019pt_BR
dc.identifier.issn1806-9460pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/70454-
dc.description.resumoBACKGROUND: Older adults with a range of comorbidities are often prescribed multiple medications, which favors drug interactions. OBJECTIVES: To establish the frequency of potential drug interactions in prescriptions at hospital discharge among older adults and to identify the associated factors. DESIGN AND SETTING: Cross-sectional study conducted in a public hospital. METHODS: An initial face-to-face interview, data collection from the electronic medical records (covering sociodemographic, clinical, functional and drug therapy-related variables) and telephone follow-up after discharge were conducted to confirm the medication prescribed at discharge. Drug interactions were identified through the Micromedex DrugReax software, along with interactions that should be avoided among the elderly, as per the 2015 American Geriatric Society/Beers criteria. Multivariable logistic regression was performed. RESULTS: Potential for drug interactions was identified in the discharge drug therapy of 67.8% of the 255 older adults evaluated (n = 172), and 54.5% (n = 145) of the drug interactions were major. Among the drug interactions that should be avoided among older adults, those that increase the risk of falls were the most frequent. The drug interactions thus identified were independently associated with polypharmacy (odds ratio, OR = 12.62; 95% confidence interval, CI 6.25-25.50; P = 0.00), diabetes mellitus (OR = 2.16; 95% CI 1.05-4.44; P = 0.04), hypothyroidism (OR = 7.29; 95% CI 2.03-26.10; P = 0.00), chronic kidney disease (OR = 3.41; 95% CI 1.09-10.64; P = 0.03) and hospitalization in geriatric units (OR = 0.45; 95% CI 0.22-0.89; P = 0.02). CONCLUSION: The frequency of potential drug interactions in drug therapy prescribed at discharge for these older adults was high. Polypharmacy, diabetes mellitus, hypothyroidism and chronic kidney disease were positively associated with occurrences of drug interactions, while hospitalization in geriatric units showed an inverse association.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofSao Paulo Medical Journal-
dc.rightsAcesso Abertopt_BR
dc.subjectDrug interactionspt_BR
dc.subjectFrail elderlypt_BR
dc.subjectPatient dischargept_BR
dc.subjectDrug therapypt_BR
dc.subject.otherInterações medicamentosaspt_BR
dc.subject.otherIdoso fragilizadopt_BR
dc.subject.otherAlta do pacientept_BR
dc.subject.otherTerapia medicamentosapt_BR
dc.titlePotential drug interactions in drug therapy prescribed for older adults at hospital discharge: cross-sectional study.pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/spmj/a/LThYwWW8TnK8JTC8sBV3c4w#pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8842-3643pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6551-4403pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0017-7338pt_BR
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