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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/70587
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dc.creatorRafael César Gonçalves Pereirapt_BR
dc.creatorFernanda Cristina Gontijo Evangelistapt_BR
dc.creatorValtair Severino dos Santos Júniorpt_BR
dc.creatorAdriano de Paula Sabinopt_BR
dc.creatorVinícius Gonçalves Maltarollopt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorLucienir Pains Duartept_BR
dc.date.accessioned2024-07-15T18:39:19Z-
dc.date.available2024-07-15T18:39:19Z-
dc.date.issued2020-
dc.citation.volume17pt_BR
dc.citation.issue12pt_BR
dc.citation.spagee2000773pt_BR
dc.identifier.doihttps://doi.org/10.1002/cbdv.202000773pt_BR
dc.identifier.issn1612-1880pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/70587-
dc.description.resumoCheiloclinium cognatum (Miers) A.C.Sm. is an endemic species of Brazilian Cerrado that belongs to Celastraceae family. The phytochemical study of C. cognatum branches led to the identification of ten triterpenoids (TPs), 3β-acyloxyurs-12-ene (1), friedelin (2), β-friedelinol (3), glut-5-en-3β-ol (4), α-amyrin (5), β-amyrin (6), β-sitosterol (7), canophyllol (8), 29-hydroxyfriedelan-3-one (9) and friedelane-3β,29-diol (10). TPs 4, 5 and 6 are described for the first Cheiloclinium genus and TPs 8 and 9 were isolated in expressive amounts. Their cytotoxic activities were evaluated against THP-1 and K562 leukemia cell lines. TPs 3 and 5 were the most active, exhibiting lower or similar IC50 against both cell lines when compared to the controls. Their mechanisms of action were investigated suggesting an intrinsic mitochondrial pathway of apoptosis evidenced by up-regulation of BAK mRNA expression. Chemometric studies indicated that their activities may be related to their molecular size and shape as well as electronic interactions of C-3 hydroxy group with molecular targets.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofChemistry & Biodiversitypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectTriterpenoidspt_BR
dc.subjectCheiloclinium cognatumpt_BR
dc.subjectCelastraceaept_BR
dc.subjectAcute leukemiapt_BR
dc.subjectChronic leukemiapt_BR
dc.subject.otherQuímica vegetalpt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherLeucemiapt_BR
dc.subject.otherApoptosept_BR
dc.subject.otherQuimiometriapt_BR
dc.subject.otherCelastraceaept_BR
dc.subject.otherTerpeniospt_BR
dc.titleCytotoxic activity of triterpenoids from Cheiloclinium cognatum branches against chronic and acute leukemia cell linespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000773pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1600-7621pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4682-397Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4291-8624pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8562-8689pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9675-5907pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8885-6625pt_BR
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