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http://hdl.handle.net/1843/70587| Tipo: | Artigo de Periódico |
| Título: | Cytotoxic activity of triterpenoids from Cheiloclinium cognatum branches against chronic and acute leukemia cell lines |
| Autor(es): | Rafael César Gonçalves Pereira Fernanda Cristina Gontijo Evangelista Valtair Severino dos Santos Júnior Adriano de Paula Sabino Vinícius Gonçalves Maltarollo Rossimiriam Pereira de Freitas Lucienir Pains Duarte |
| Resumo: | Cheiloclinium cognatum (Miers) A.C.Sm. is an endemic species of Brazilian Cerrado that belongs to Celastraceae family. The phytochemical study of C. cognatum branches led to the identification of ten triterpenoids (TPs), 3β-acyloxyurs-12-ene (1), friedelin (2), β-friedelinol (3), glut-5-en-3β-ol (4), α-amyrin (5), β-amyrin (6), β-sitosterol (7), canophyllol (8), 29-hydroxyfriedelan-3-one (9) and friedelane-3β,29-diol (10). TPs 4, 5 and 6 are described for the first Cheiloclinium genus and TPs 8 and 9 were isolated in expressive amounts. Their cytotoxic activities were evaluated against THP-1 and K562 leukemia cell lines. TPs 3 and 5 were the most active, exhibiting lower or similar IC50 against both cell lines when compared to the controls. Their mechanisms of action were investigated suggesting an intrinsic mitochondrial pathway of apoptosis evidenced by up-regulation of BAK mRNA expression. Chemometric studies indicated that their activities may be related to their molecular size and shape as well as electronic interactions of C-3 hydroxy group with molecular targets. |
| Assunto: | Química vegetal Agentes antineoplásicos Leucemia Apoptose Quimiometria Celastraceae Terpenios |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de Acesso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1002/cbdv.202000773 |
| URI: | http://hdl.handle.net/1843/70587 |
| Data do documento: | 2020 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000773 |
| metadata.dc.relation.ispartof: | Chemistry & Biodiversity |
| Aparece nas coleções: | Artigo de Periódico |
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