Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/70779| Type: | Artigo de Periódico |
| Title: | A UBI 31-38 peptide-coumarin conjugate: photophysical features, imaging tracking and synergism with Amphotericin B against Cryptococcus |
| Authors: | Soraya Maria Zandim Maciel Dias Ferreira Hellem Cristina Silva Carneiro Rosemeire Brondi Alves Ana Carolina Silva Batista Eufrânio Nunes da Silva Júnior Gleiston Gonçalves Dias Jarbas Magalhães Resende Daniel de Assis Santos Débora L. Oliveira Marcio Lourenço Rodrigues Rossimiriam Pereira de Freitas |
| Abstract: | Cryptococcosis is a fungal disease of global significance for which new effective treatments are needed. The conjugation of the synthetic antimicrobial peptide fragment UBI 31-38 to a coumarin derivative showed to be an effective approach for the design of a novel anticryptococcal agent. In addition to antifungal activity, the conjugate exhibited intense fluorescence, which could be valuable for mechanistic investigations of this molecule. In this work, we studied the photophysical properties of the conjugate and confocal scanning laser microscopy was used to inspect the distribution of the peptide-coumarin conjugate in Cryptococcus cell. The synergism of this compound with amphotericin B or fluconazole against C. gattii and C. neoformans strains was also investigated. The results indicated that the fluorescent conjugate alone as well as its combination with amphotericin B are promising tools against cryptococcosis. |
| Subject: | Química farmacêutica Microscopia Sistemas de varredura Anfotericina B Atividade antifúngica |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MICROBIOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | http://dx.doi.org/10.2174/1568026618666180221113137 |
| URI: | http://hdl.handle.net/1843/70779 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://www.eurekaselect.com/article/88696 |
| metadata.dc.relation.ispartof: | Current Topics in Medicinal Chemistry |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.