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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/72109
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dc.creatorFabíola S. dos Santospt_BR
dc.creatorGleiston Gonçalves Diaspt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorLucas da Silva Santospt_BR
dc.creatorGuilherme Ferreira de Limapt_BR
dc.creatorHélio Anderson Duartept_BR
dc.creatorCarlos Alberto de Simonept_BR
dc.creatorLidia Maria Silva Lopes Rezendept_BR
dc.creatorMonique Jacob Xavier Viannapt_BR
dc.creatorJosé Raimundo Corrêapt_BR
dc.creatorBrenno Amaro da Silveira Netopt_BR
dc.creatorEufrânio Nunes da Silva Júniorpt_BR
dc.date.accessioned2024-07-30T14:15:44Z-
dc.date.available2024-07-30T14:15:44Z-
dc.date.issued2017-
dc.citation.volume2017pt_BR
dc.citation.issue26pt_BR
dc.citation.spage3763pt_BR
dc.citation.epage3773pt_BR
dc.identifier.doihttps://doi.org/10.1002/ejoc.201700227pt_BR
dc.identifier.issn1875-6638pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72109-
dc.description.resumoWe describe herein a synthetic strategy for the synthesis of new fluorescent imidazole and phenazine derivatives synthesized from lapachol, a naturally occurring naphthoquinone isolated from Tabebuia species (ipê tree). The photophysical properties and computational details of these compounds have been studied, aiming at gaining a complete understanding of the potential of these derivatives as probes capable of staining mitochondria selectively. Cell imaging experiments proved the capacity of the imidazole derivatives as selective fluorescent mitochondrial imaging probes. These heterocycles present the same staining patterns as MitoTracker Red, corroborating the potential of these compounds as new mitochondria markers permeable to the cell membrane.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Organic Chemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectQuinonespt_BR
dc.subjectHeterocyclespt_BR
dc.subjectImaging agentspt_BR
dc.subjectFluorescencept_BR
dc.subjectRedox modificationpt_BR
dc.subject.otherQuinonapt_BR
dc.subject.otherNaftoquinonapt_BR
dc.subject.otherCompostos heterocíclicospt_BR
dc.subject.otherNitrogêniopt_BR
dc.subject.otherFluorescênciapt_BR
dc.subject.otherSíntesept_BR
dc.subject.otherSondas fluorescentespt_BR
dc.titleRedox center modification of lapachones toward the syntheses of nitrogen heterocycles as selective fluorescent mitochondrial imaging probespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.201700227pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4952-756Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0311-3831pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8164-4454pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6622-710Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2752-5395pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1281-5453pt_BR
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