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http://hdl.handle.net/1843/72261| Type: | Artigo de Periódico |
| Title: | Synthesis of novel cinnamides and a bis cinnamate bearing 1,2,3-triazole functionalities with antiproliferative and antimetastatic activities on melanoma cells |
| Authors: | Fabíola Suelen dos Santos Juliana Alves do Vale Lucas da Silva Santos Talita Bárbara Gontijo Graziela Domingues de Almeida Lima Leandro Licursi de Oliveira Mariana Machado Neves Róbson Ricardo Teixeira Rossimiriam Pereira de Freitas |
| Abstract: | The present investigation describes the synthesis of novel cinnamides and a bis cinnamate bearing 1,2,3-triazole functionalities and investigation of their antiproliferative and antimetastatic effects on melanoma cells. The necessity for the development of new chemotherapeutic agents for melanoma treatment motivated this work. Sixteen derivatives were obtained with yields ranging from 23-81% and fully characterized by spectroscopic (1H and 13C nuclear magnetic resonance, infrared) and spectrometric high resolution mass spectrometry (HRMS) techniques. The derivatives were in vitro evaluated against B16-F10 murine melanoma cell line. The most effective compound (a bis cinnamate) (6b) reduced the melanoma cell viability, generated cell cycle arrest, and influenced the metastatic behavior of melanoma cells by decreasing migration, invasion, and colony formation. Based on these findings, it is believed that compound 6b may represent an interesting scaffold to be explored toward the development of new antimelanoma agents. |
| Subject: | Síntese Triazóis Células - Proliferação Melanoma Metástase Quimioterapia Ressonância magnética nuclear Espectrometria de massa |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | http://dx.doi.org/10.21577/1984-6835.20180029 |
| URI: | http://hdl.handle.net/1843/72261 |
| Issue Date: | 2021 |
| metadata.dc.url.externa: | https://www.scielo.br/j/jbchs/a/YrhrWdzX46GHtdHSCW6dbPn |
| metadata.dc.relation.ispartof: | Journal of the Brazilian Chemical Society |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Synthesis of novel cinnamides and a bis cinnamate.pdf | 847.44 kB | Adobe PDF | View/Open |
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