Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/72428| Type: | Artigo de Periódico |
| Title: | Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils |
| Authors: | Maria E. A. Pinto Sthéfane G. Araújo Marcela L. Morais Nívea P. Sá Caroline M. Lima Carlos Augusto Rosa Ezequias P. Siqueira Susana Johann Luciana A. R. S. Lima |
| Abstract: | Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity. |
| Abstract: | Ésteres metílicos de ácidos graxos (FAMEs) foram obtidos a partir de óleos vegetais de soja, milho e girassol. O presente estudo teve como foco avaliar a atividade antifúngica dos FAMEs principalmente contra Paracoccidioides spp., bem como testar a interação desses compostos com antifúngicos comerciais e também seu potencial antioxidante. FAMEs apresentaram valores pequenos de IC50 (1,86-9,42 μg/mL). Todos os três FAMEs testados apresentaram atividade antifúngica contra isolados de Paracoccidioides spp. com valores de CIM variando de 15,6-500 µg/mL. FAMEs de girassol exibiram atividade antifúngica que se estendeu também a outros gêneros, com CIM de 15,6 μg/mL contra Candida glabrata e C. krusei e 31,2 μg/mL contra C. parapsilosis. FAMEs exibiram um efeito sinérgico com o itraconazol. A atividade antifúngica dos FAMEs contra isolados de Paracoccidioides spp. é provavelmente devido à presença de linoleato de metila, o principal composto presente em todos os três FAMEs. Os resultados obtidos indicam o potencial dos FAMEs como fontes de atividade antifúngica e antioxidante. |
| Subject: | Antimicóticos Antioxidantes Ésteres Óleos de plantas |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE BOTÂNICA ICB - DEPARTAMENTO DE MICROBIOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1590/0001-3765201720160908 |
| URI: | http://hdl.handle.net/1843/72428 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.scielo.br/j/aabc/a/pX3TCGgRQ3jJYscSxXFX4Rh/?lang=en# |
| metadata.dc.relation.ispartof: | Anais da Academia Brasileira de Ciências |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils.pdf | 625.05 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.