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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/72642
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dc.creatorHelvécio Marangon Juniorpt_BR
dc.creatorVictória Vasconcellos Moreira Melopt_BR
dc.creatorÂngela Braga Caixetapt_BR
dc.creatorGiovanna Ribeiro Soutopt_BR
dc.creatorPaulo Eduardo Alencar Souzapt_BR
dc.creatorMaria Cassia Ferreira de Aguiarpt_BR
dc.creatorMartinho Campolina Rebello Hortapt_BR
dc.date.accessioned2024-08-05T20:03:40Z-
dc.date.available2024-08-05T20:03:40Z-
dc.date.issued2018-11-14-
dc.citation.volume14 Head and neck pathologypt_BR
dc.citation.issueassunto cancer oralpt_BR
dc.citation.spage1ept_BR
dc.citation.epage1ept_BR
dc.identifier.doihttps://doi.org/10.1007/s12105-018-0985-4pt_BR
dc.identifier.issn1936-0568pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72642-
dc.description.resumoTumor budding is a prognostic marker for oral squamous cell carcinoma (OSCC) characterized by the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. Aldehyde dehydrogenase-1 (ALDH1) is associated with tumorigenesis, linked to treatment resistance and shown to identify cancer stem cells (CSC)-like cells. This study aimed to evaluate the expression of ALDH1 and its association with tumor budding in OSCC. Immunohistochemistry was employed in 163 OSCC samples to identify pancytokeratin (AE1/AE3) and ALDH1. While pancytokeratin (AE1/AE3) identified squamous tumor buds, the CSC-like cells were identified using ALDH1. A Chi square test was used to evaluate association between ALDH1 expression and tumor budding, while McNemar’s test was used to identify differences in ALDH1 expression between the budding area and the area outside the budding. A positive expression of ALDH1 was observed in 47.24% of the samples and in 70% of anatomic locations affected. No association was observed between ALDH1 expression and tumor budding (p > 0.05). In tumors with high-intensity tumor budding, ALDH1 expression was higher in the budding area than in the area outside the budding (p < 0.05). The finding that tumor bud cells in OSCC show phenotypic characteristics of CSC-like cells reinforces the relevance of tumor budding in determining the biological behavior of this malignant neoplasm. Moreover, the presence of CSC-like cells in nearly half of evaluated samples of OSCC and in most of the affected anatomic locations is in accordance with the CSC model of oral carcinogenesis.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofHead and Neck Pathologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectOral squamous cell carcinomapt_BR
dc.subjectBuddingpt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subject.otherAldehyde dehydrogenase 1 familypt_BR
dc.subject.otherNeoplastic stem cellspt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherCarcinoma, squamous cellpt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherCarcinogenesispt_BR
dc.subject.otherKeratinspt_BR
dc.subject.otherAssociationpt_BR
dc.subject.otherEvaluation studypt_BR
dc.subject.otherPhenotypept_BR
dc.subject.otherGene expressionpt_BR
dc.titleImmunolocalization of cancer stem cells marker aldh1 and its association with tumor budding in oral squamous cell carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s12105-018-0985-4pt_BR
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