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http://hdl.handle.net/1843/72649| Type: | Artigo de Periódico |
| Title: | A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models |
| Authors: | Nivea Pereira de Sá Eleftherios Mylonakis Carlos Augusto Rosa Daniel Assis Santos Susana Johann Caroline M. Lima Juliana R. A. Santos Marliete Carvalho Costa Patricia P. Barros Juliana Campos Junqueira Jéssica Aparecida Vaz Renata Barbosa de Oliveira Beth Burgwyn Fuchs |
| Abstract: | Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential. |
| Abstract: | Objetivo: Neste trabalho testamos 2-(2-(ciclohexilmetileno)hidrazinil)-4-feniltiazol (CHT) contra Cryptococcus spp. e Candida albicans. Métodos: Foi avaliada a capacidade da CHT de atuar no biofilme e também de interferir na adesão de C. albicans, bem como a eficiência da CHT em modelos invertebrados e murinos de criptococose e candidíase. Resultados e conclusão: No presente trabalho verificamos que a CHT inibe Cryptococcus e C. albicans afetando o biofilme em ambos e inibe a adesão de Candida às células bucais humanas. Quando avaliamos in vivo, a CHT prolongou a sobrevivência de Galleria mellonella após infecções por Cryptococcusgattii, Cryptococcusneoformans ou C. albicans e promoveu redução na carga fúngica para os órgãos nos modelos murinos. Estes resultados demonstram o potencial terapêutico da CHT. |
| Subject: | Antifúngicos Candida albicans Camundongos Tiazóis Virulência |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICB - DEPARTAMENTO DE BOTÂNICA ICB - DEPARTAMENTO DE MICROBIOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.4155/fsoa-2018-0001 |
| URI: | http://hdl.handle.net/1843/72649 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://www.tandfonline.com/doi/full/10.4155/fsoa-2018-0001 |
| metadata.dc.relation.ispartof: | Future Science OA |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models.pdf | 805.79 kB | Adobe PDF | View/Open |
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