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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/72664
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dc.creatorNathálya Gardênia de Holanda Marinho Nogueirapt_BR
dc.creatorGuilherme Menezes Lagept_BR
dc.creatorDébora Marques de Mirandapt_BR
dc.creatorMaicon Rodrigues Albuquerquept_BR
dc.creatorBárbara de Paula Ferreirapt_BR
dc.creatorMarco Túlio Silva Batistapt_BR
dc.creatorJuliana Otoni Parmapt_BR
dc.creatorTércio Apolinário-Souzapt_BR
dc.creatorLucas Eduardo Antunes Bicalhopt_BR
dc.creatorHerbert Ugrinowitschpt_BR
dc.date.accessioned2024-08-05T20:44:52Z-
dc.date.available2024-08-05T20:44:52Z-
dc.date.issued2020-
dc.citation.volume168pt_BR
dc.citation.spage1pt_BR
dc.citation.epage10pt_BR
dc.identifier.doi10.1016/j.nlm.2020.107157pt_BR
dc.identifier.issn1074-7427pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72664-
dc.description.resumoDifferences in motor learning can be partially explained by differences in genotype. The catechol-O-methyltransferase (COMT) Val158Met polymorphism regulates the dopamine (DA) availability in the prefrontal cortex modulating motor learning and performance. Given the differences in tonic and phasic DA transmission, this study aimed to investigate whether the greater cognitive flexibility associated with the Val allele would favor the learning of movement parametrization, while the greater cognitive stability associated with the Met allele favors the acquisition of the movement pattern. Furthermore, we investigated if the genotypic characteristics impact visual scanning of information related to parametrization and to the movement pattern, and the level of cortical connectivity associated with motor planning and control. Performance and learning of a sequential motor task were compared among three genotypes (Val/Val, Val/Met, and Met/Met), as well as their oculomotor behavior and level of cortical coherence. The findings show that the cognitive flexibility promoted by the Val allele is associated with a better parametrization. The search for information through visual scanning was specific to each genotype. Also, a greater cortical connectivity associated with the Val allele was found. The combined study of behavioral, electrophysiological and molecular levels of analysis showed that the cognitive stability and flexibility associated with the COMT alleles, influence specific aspects of motor learning.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofNeurobiology of Learning and Memory-
dc.rightsAcesso Restritopt_BR
dc.subject.otherAprendizagem motorapt_BR
dc.subject.otherCapacidade motorapt_BR
dc.subject.otherPolimorfismo (Genética)pt_BR
dc.titleMotor learning and COMT Val158met polymorphism: analyses of oculomotor behavior and corticocortical communicationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1074742720300010pt_BR
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