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http://hdl.handle.net/1843/72668| Type: | Artigo de Periódico |
| Title: | Immunoexpression of SOX-2 in oral leukoplakia |
| Authors: | Suelen Teixeira Luiz Rafaela Scariot de Moraes Maria Cassia Ferreira de Aguiar Sérgio Aparecido Ignácio Bruno Correia Jham Lucia de Noronha Aline Cristina Batista Rodrigues Johann Filipe Modolo Siqueira Izabela Mozzer Emanuela Carla dos Santos Seigo Nagashima Ana Paula Camargo Martins Marina Luise Viola de Azevedo Luciana Reis Azevedo Alanis Ana Maria Grégio Hardy |
| Abstract: | Objective: This study was conducted to correlate and compare the immunoexpression of sex-determining region Y-box 2 (SOX-2) in oral leukoplakia (OL) lesions with that in normal buccal mucosa (control). Materials and methods: In this observational study, OL with low-risk (n = 34) and high-risk (n = 33) dysplasia and control samples (n = 25) were subjected to immunohistochemical analysis for SOX-2. In the epithelium, SOX-2 positive and negative cells, as well as semiautomatic segmentation of the immunopositive nuclear area were counted. Statistical tests included chi-square, one-way analysis of variance, Tukey, and Games-Howell. The level of significance was 5%. Results: Groups with OL lesions (low and high-risk) showed higher mean numbers of SOX-2 positive cells (63.47 ± 25.70 and 68.18 ± 21.17) compared to the control group (45.85 ± 27.38) (p = 0.00). Groups with OL lesions (low and high-risk) exhibited higher mean positive nuclear area (0.24 ± 0.47 and 1.09 ± 2.06) compared to the control group (0.00 ± 0.01) (p = 0.01). Conclusion: Oral leukoplakia lesions showed a higher expression of SOX-2, suggesting its contribution to the pathogenesis of OL. |
| Subject: | Mouth Leukoplakia Mouth neoplasms SOXB2 transcription factors Immunohistochemistry Immune system Gene expression |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/odi.12922 |
| URI: | http://hdl.handle.net/1843/72668 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/odi.12922 |
| metadata.dc.relation.ispartof: | Oral Diseases |
| Appears in Collections: | Artigo de Periódico |
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