1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/73163
Full metadata record
DC FieldValueLanguage
dc.creatorCéline Dardpt_BR
dc.creatorBaptiste Leforestierpt_BR
dc.creatorFlaviane Francisco Hiláriopt_BR
dc.creatorMohamed Dit Mady Traorépt_BR
dc.creatorMarie-Ange Lespinassept_BR
dc.creatorBasile Pérèspt_BR
dc.creatorMarie-Carmen Molinapt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorAnne Miletpt_BR
dc.creatorDanièle Maubonpt_BR
dc.creatorYung-Sing Wongpt_BR
dc.date.accessioned2024-08-06T23:05:03Z-
dc.date.available2024-08-06T23:05:03Z-
dc.date.issued2021-
dc.citation.volume26pt_BR
dc.citation.issue24pt_BR
dc.citation.spage7506pt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules26247506pt_BR
dc.identifier.issn1420-3049pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/73163-
dc.description.resumoFR235222 is a natural tetra-cyclopeptide with a strong inhibition effect on histone deacetylases, effective on mammalian cells as well as on intracellular apicomplexan parasites, such as Toxoplasma gondii, in the tachyzoite and bradyzoite stages. This molecule is characterized by two parts: the zinc-binding group, responsible for the binding to the histone deacetylase, and the cyclic tetrapeptide moiety, which plays a crucial role in cell permeability. Recently, we have shown that the cyclic tetrapeptide coupled with a fluorescent diethyl-amino-coumarin was able to maintain properties of cellular penetration on human cells. Here, we show that this property can be extended to the crossing of the Toxoplasma gondii cystic cell wall and the cell membrane of the parasite in its bradyzoite form, while maintaining a high efficacy as a histone deacetylase inhibitor. The investigation by molecular modeling allows a better understanding of the penetration mechanism.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMoleculespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCyclopeptidespt_BR
dc.subjectHistone deacetylasept_BR
dc.subjectToxoplasma gondiipt_BR
dc.subjectBradyzoitept_BR
dc.subjectCell-permeable agentpt_BR
dc.subjectMolecular dynamicspt_BR
dc.subject.otherToxoplasma gondiipt_BR
dc.subject.otherDinâmica molecularpt_BR
dc.subject.otherPeptídiospt_BR
dc.subject.otherMoléculaspt_BR
dc.titleCrossing of the cystic barriers of Toxoplasma gondii by the fluorescent coumarin tetra-cyclopeptidept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/1420-3049/26/24/7506pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5843-0842pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8547-6021pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0784-6450pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1480-4451pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9080-7638pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1038-9681pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Crossing of the cystic barriers of Toxoplasma gondii by the fluorescent coumarin tetra-cyclope.pdf3.82 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.