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http://hdl.handle.net/1843/74279| Type: | Artigo de Periódico |
| Title: | Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy |
| Authors: | Eduardo Morato de Oliveira Rafael Soares Guieiro Bárbara Lima Cruz Maria Cássia Ferreira de Aguiar Janine Mayra da Silva Tarcília Aparecida da Silva Patrícia Carlos Caldeira |
| Abstract: | Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for head and neck cancer treatment, compared with non-irradiated individuals. Total unstimulated saliva was collected for ELISA assay analysis of receptor activator for nuclear factor κ B (RANK) and its ligand (RANK-L), osteoprotegerin, matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor, and epidermal growth factor. Statistics were performed, and revealed that salivary RANK (p = 0.0304), RANK-L (p = 0.0005), matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2 (p = 0.0067), vascular endothelial growth factor (p = 0.0060), and epidermal growth factor (p < 0.0001) were reduced in patients, compared with the control group. Osteoprotegerin did not differ between the groups (p = 0.3765). Salivary biomarkers did not differ according to radiotherapy completion time (p > 0.05). In conclusion, the lower output of the salivary molecules – essential for bone remodeling and tissue repair – may disrupt tissue homeostasis and play a role in the pathogenesis of the radiotherapy-induced deleterious effects in the oral cavity. |
| Subject: | Saliva Radiotherapy Bone remodeling Bone remodeling Mouth neoplasms Head and neck neoplasms Biomarkers Receptor activator of nuclear factor-kappa B RANK ligand Osteoprotegerin Osteoprotegerin Matrix Metalloproteinase 9 Tissue inhibitor of Metalloproteinase-2 Endothelial growth factors Blood Epidermal growth factor Homeostasis Mouth |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1590/1807-3107bor-2021.vol35.0079 |
| URI: | http://hdl.handle.net/1843/74279 |
| Issue Date: | 15-Jun-2021 |
| metadata.dc.url.externa: | https://www.scielo.br/j/bor/a/bHKgmrxDGbmgsTKLykFQRdH/ |
| metadata.dc.relation.ispartof: | Brazilian Oral Research |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy.pdf | 249.49 kB | Adobe PDF | View/Open |
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