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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/74733
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dc.creatorLauren Frenzel Schuchpt_BR
dc.creatorKarolina Skarlet Silva Vianapt_BR
dc.creatorJosé Alcides Almeida de Arrudapt_BR
dc.creatorLucas Guimarães Abreupt_BR
dc.creatorMaria Cássia Ferreira de Aguiarpt_BR
dc.creatorVanessa Fátima Bernardespt_BR
dc.date.accessioned2024-08-22T20:50:31Z-
dc.date.available2024-08-22T20:50:31Z-
dc.date.issued2023-01-06-
dc.citation.volume37 Brazilian Oral Researchpt_BR
dc.citation.issue8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage16pt_BR
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2023.vol37.0008pt_BR
dc.identifier.issn1807-3107pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/74733-
dc.description.resumoScientific evidence about genetic and molecular changes in oral squamous cell carcinoma (OSCC) among smokers and non-smokers is inconclusive. This systematic review and meta-analysis assessed the effects of tobacco on the DNA of individuals with OSCC based on protein mutations. Electronic searches were conducted on PubMed, Ovid, Web of Science, and Scopus to identify observational studies published up to January/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. The certainty of the evidence was evaluated. Twenty-three studies assessing 4,060 individuals (2,967 smokers vs. 1,093 non-smokers) were included in this review. Fifteen groups of proteins/genes were investigated. Analysis of the quality of articles revealed low risk of bias in most studies. The certainty of the evidence was very low. The meta-analysis confirmed no significant difference between smokers and non-smokers with respect to damage to GSTM1 (OR: 0.60; 95%CI: 0.30–1.18), GSTT1 (OR: 1.18; 95%CI:0.49–2.83), hydrolase proteins (Ku70 and Ku80) (OR: 0.74; 95%CI: 0.18–3.05), and transferase proteins (GSTM1, GSTT1, GSTM3) (OR: 0.74; 95%CI: 0.47–1.18). Most of the studies included showed that smokers are more likely to exhibit genetic instability. However, the meta-analysis revealed that smokers do not necessarily have more genetic alterations in the DNA than non-smokers.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Oral Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDNA damagept_BR
dc.subject.otherDNA damagept_BR
dc.subject.otherHead and neck neoplasmspt_BR
dc.subject.otherMeta-analysispt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherSystematic reviewpt_BR
dc.subject.otherTobacco smokingpt_BR
dc.subject.otherPTEN phosphohydrolasept_BR
dc.subject.otherCarcinoma, squamous cellpt_BR
dc.subject.otherGenespt_BR
dc.subject.otherProteinspt_BR
dc.titleEffects of tobacco on the DNA of smokers and non-smokers affected by OSCC - systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bor/a/bYtHcQCh7j7PRBCkBj3RpYh/#pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9273-376Xpt_BR
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