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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/76357
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dc.creatorYuri de Freitas Regopt_BR
dc.creatorMarcelo Pereira Queirozpt_BR
dc.creatorTiago Oliveira Britopt_BR
dc.creatorPriscila Goes Carvalhopt_BR
dc.creatorVagner Tebaldi de Queirozpt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorFernando Cesar Macedo Juniorpt_BR
dc.date.accessioned2024-09-11T19:14:15Z-
dc.date.available2024-09-11T19:14:15Z-
dc.date.issued2018-
dc.citation.volume13pt_BR
dc.citation.spage69pt_BR
dc.citation.epage100pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jare.2018.05.003pt_BR
dc.identifier.issn2090-1232pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/76357-
dc.description.resumoUreases are enzymes that hydrolyze urea into ammonium and carbon dioxide. They have received considerable attention due to their impacts on living organism health, since the urease activity in microorganisms, particularly in bacteria, are potential causes and/or factors contributing to the persistence of some pathogen infections. This review compiles examples of the most potent antiurease organic substances. Emphasis was given to systematic screening studies on the inhibitory activity of rationally designed series of compounds with the corresponding SAR considerations. Ureases of Canavalia ensiformis, the usual model in antiureolytic studies, are emphasized. Although the active site of this class of hydrolases is conserved among bacteria and vegetal ureases, the same is not observerd for allosteric site. Therefore, inhibitors acting by participating in interactions with the allosteric site are more susceptible to a potential lack of association among their inhibitory profile for different ureases. The information about the inhibitory activity of different classes of compounds can be usefull to guide the development of new urease inhibitors that may be used in future in small molecular therapy against pathogenic bacteria.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Advanced Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectUrease inhibitorspt_BR
dc.subjectUreapt_BR
dc.subjectThioureapt_BR
dc.subjectHeterocyclespt_BR
dc.subjectPhosphorated compoundspt_BR
dc.subject.otherUrease - Inibidorespt_BR
dc.subject.otherUréiapt_BR
dc.subject.otherTiouréiapt_BR
dc.subject.otherCompostos heterociclicospt_BR
dc.subject.otherCompostos de fósforopt_BR
dc.subject.otherAgentes antibacterianospt_BR
dc.titleA review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteriapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2090123218300560?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5036-9995pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4483-2119pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8170-125Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4230-1309pt_BR
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