Oral melanoacanthoma: clinicopathological and immunohistochemical features of a case series and a scoping review

Thalita Soares Tavares; Sandra Beatriz Chaves Tarquínio; Patrícia Carlos Caldeira; Adriana Aparecida Silva da Costa; Felipe da Mata Camargos; Ricardo Santiago Gomez; Cassiano Francisco Weege Nonaka; Pollianna Muniz Alves; Elismauro Francisco Mendonça; Sebastião Silvério Sousa-Neto; Ana Carolina Uchoa Vasconcelos

Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/76412

Type:	Artigo de Periódico
Title:	Oral melanoacanthoma: clinicopathological and immunohistochemical features of a case series and a scoping review
Authors:	Thalita Soares Tavares Sandra Beatriz Chaves Tarquínio Patrícia Carlos Caldeira Adriana Aparecida Silva da Costa Felipe da Mata Camargos Ricardo Santiago Gomez Cassiano Francisco Weege Nonaka Pollianna Muniz Alves Elismauro Francisco Mendonça Sebastião Silvério Sousa-Neto Ana Carolina Uchoa Vasconcelos
Abstract:	Background: This study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics. Methods: Nine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin-eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched. Results: Case series: The mean age was 46.8 years (female-to-male ratio 2:1). Lesion's mean size was 11.0 mm (±9.3). Lesions were mainly macular (77.8%) with brown or black coloration (88.9%) and often affected multiple sites (44.4%). The evolution time ranged from 15 days to 96 months. Lesions commonly showed epithelial acanthosis (66.7%), spongiosis (55.6%), exocytosis (77.8%), melanin incontinence (88.9%), and inflammatory infiltrate in the lamina propria (77.8%), from which all showed lymphocytes. TRP2-positive melanocytes were identified in the basal and spinous layer of all cases, and in the superficial layer of three cases. CD3-positive cells predominate over the CD20-positive. Scoping review: 85 cases of oral melanoacanthoma were retrieved from 55 studies. Patients were primarily female (female-to-male ratio 2.2:1), black-skinned (64.1%), with a mean age of 36.13 (± 17.24). Lesions were flat (81.9%), often brown (62.4%). Buccal mucosa was the preferred site (32.9%), followed by multiple sites (28.2%). Conclusion: Oral melanoacanthoma mainly affects women across a wide age range, with lesions commonly appearing as brown/black macules, particularly on the buccal mucosa. TRP2-positive melanocytes and T-lymphocytes were consistently found and could participate in oral melanoacanthoma pathogenesis.
Subject:	Melanocytes Mouth mucosa Pigmentation disorders T-lymphocytes Biopsy Electronic health records Immunohistochemistry
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE CLÍNICA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1111/jop.13495
URI:	http://hdl.handle.net/1843/76412
Issue Date:	2023
metadata.dc.url.externa:	https://onlinelibrary.wiley.com/doi/10.1111/jop.13495
metadata.dc.relation.ispartof:	Journal of Oral Pathology & Medicine
Appears in Collections:	Artigo de Periódico

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