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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/76850
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dc.creatorTamires Cunha Almeidapt_BR
dc.creatorLuis Henrique Gonzaga Ribeiropt_BR
dc.creatorLuzia Braga Ferreira dos Santospt_BR
dc.creatorCleiton Moreira da Silvapt_BR
dc.creatorRenata Tupinambá Branquinhopt_BR
dc.creatorMarta de Lanapt_BR
dc.creatorFernanda Ramos Gadelhapt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.date.accessioned2024-09-24T18:28:00Z-
dc.date.available2024-09-24T18:28:00Z-
dc.date.issued2018-
dc.citation.volume108pt_BR
dc.citation.spage1703pt_BR
dc.citation.epage1711pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2018.09.176pt_BR
dc.identifier.issn0753-3322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/76850-
dc.description.resumoChagas disease is a major health problem not only in Latin America but also in Europe and North America due to the spread of this disease into nonendemic areas. In terms of global burden, this major tropical infection is considered to be one of the most neglected diseases, and there are currently only two available chemotherapies: benznidazole and nifurtimox. Unfortunately, although these chemotherapies are beneficial in the acute phase of the disease, benznidazole and nifurtimox lead to significant side effects, including hepatitis and neurotoxicity. Therefore, the search for and development of more effective, safe and inexpensive anti-Trypanosoma cruzi drugs are required. In this work, a series of 10 nitroaromatic Schiff bases bearing different (nitro) aromatic rings-was synthesized. Subsequently, the in vitro and in vivo anti-T. cruzi activities of the Schiff bases were investigated, as well as the in vivo toxicity and the biological effects. The basic structure of the most promising in vivo Schiff base, 10 would be useful in the synthesis of new compounds for Chagas disease treatment.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiomedicine & Pharmacotherapypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSchiff basespt_BR
dc.subjectAldiminespt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectTrypanocidal activitypt_BR
dc.subjectChagas diseasept_BR
dc.subjectProtozoan parasitept_BR
dc.subject.otherSchiff, Bases dept_BR
dc.subject.otherTripanossomopt_BR
dc.subject.otherChagas, Doença dept_BR
dc.titleSynthesis, in vitro and in vivo anti-trypanosoma cruzi and toxicological activities of nitroaromatic schiff basespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332218350078?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5584-3609pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6592-3971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9913-8971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7907-5651pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1075-8830pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
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