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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/77286
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dc.creatorIvo Souza Ferraz de Melopt_BR
dc.creatorFlávio Almeida Amaralpt_BR
dc.creatorRenata Barbosa Oliveirapt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorMárcio de Matos Coelhopt_BR
dc.creatorRenes de Resende Machadopt_BR
dc.creatorFelipe Fernandes Rodriguespt_BR
dc.creatorSarah Olivia Alves Mendes da Costapt_BR
dc.creatorAlysson Vinícius Bragapt_BR
dc.creatorMarcela Ísis Moraispt_BR
dc.creatorJéssica Aparecida Vazpt_BR
dc.creatorLeonardo da Silva Netopt_BR
dc.creatorIzabela Galvãopt_BR
dc.creatorLuzia Valentina Modolopt_BR
dc.date.accessioned2024-10-07T21:12:45Z-
dc.date.available2024-10-07T21:12:45Z-
dc.date.issued2019-
dc.citation.volume856pt_BR
dc.citation.spage172404pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2019.172404pt_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/77286-
dc.description.resumoThe gasotransmitter hydrogen sulfide (H2S) is known to regulate many pathophysiological processes. Preclinical assays have demonstrated that H2S donors exhibit anti-inflammatory and antinociceptive activities, characterized by reduction of inflammatory mediators production, leukocytes recruitment, edema and mechanical allodynia. In the present study, the effects induced by 4-methylbenzenecarbothioamide (4-MBC) in models of pain and inflammation in mice, the mechanisms mediating such effects and the H2S-releasing property of this compound were evaluated. 4-MBC spontaneously released H2S in vitro in the absence of organic thiols. Intraperitoneal (i.p.) administration of 4-MBC (100 or 150 mg/kg) reduced the second phase of the nociceptive response induced by formaldehyde and induced a long lasting inhibitory effect on carrageenan mechanical allodynia. 4-MBC antiallodynic effect was not affected by previous administration of naltrexone or glibenclamide. 4-MBC (50, 100 or 150 mg/kg, i.p.) induced a long lasting inhibitory effect on paw edema induced by carrageenan. The highest dose (150 mg/kg, i.p.) of 4-MBC inhibited tumor necrosis factor-α and CXCL1 production and myeloperoxidase activity induced by carrageenan. Mechanical allodynia and paw edema induced by carrageenan were not inhibited by the 4-MBC oxo analogue (p-toluamide). In summary, 4-MBC, an H2S releasing thiobenzamide, exhibits antinociceptive and anti-inflammatory activities. These activities may be due to reduced cytokine and chemokine production and neutrophil recruitment. The H2S releasing property is likely essential for 4-MBC activity. Our results indicate that 4-MBC may represent a useful pharmacological tool to investigate the biological roles of H2S.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Pharmacologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHydrogen sulfidept_BR
dc.subject4-Methylbenzenecarbothioamidept_BR
dc.subjectPainpt_BR
dc.subjectInflammationpt_BR
dc.subjectTumor necrosis factor-αpt_BR
dc.subjectCXCL-1pt_BR
dc.subject.otherDorpt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherFator de necrose de tumorpt_BR
dc.subject.otherAgentes antiinflamatóriospt_BR
dc.subject.otherMinerais de sulfetopt_BR
dc.subject.otherHidrogêniopt_BR
dc.title4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-α and CXCL1 production and exhibits activity in models of pain and inflammationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0014299919303474pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1695-0612pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5884-2567pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1284-1195pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7732-9988pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4554-9577pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8033-0434pt_BR
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