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http://hdl.handle.net/1843/77344| Type: | Artigo de Periódico |
| Title: | Nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome |
| Authors: | Victor Hugo Dantas Guimarães Barbhara Mota Marinho Daisy Motta Santos Gabriela da Rocha Lemos Mendes Sérgio Henrique Sousa Santos |
| Abstract: | Obesity and metabolic disorders represent a significant global health problem and the gut microbiota plays an important role in modulating systemic homeostasis. Recent evidence shows that microbiota and its signaling pathways may affect the whole metabolism and the Renin-Angiotensin System (RAS), which in turn seems to modify microbiota. The present review aimed to investigate nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome components. A description of metabolic changes was obtained based on relevant scientific literature. The molecular and physiological mechanisms that impact the human microbiome were addressed, including the gut microbiota associated with obesity, diabetes, and hepatic steatosis. The RAS interaction signaling and modulation were analyzed. Strategies including the use of prebiotics, symbiotics, probiotics, and biotechnology may affect the gut microbiota and its impact on human health. |
| Subject: | Síndrome metabólica Obesidade Sistema renina-angiotensina Homeostase |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jnutbio.2022.109252 |
| URI: | http://hdl.handle.net/1843/77344 |
| Issue Date: | Mar-2023 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0955286322003205 |
| metadata.dc.relation.ispartof: | The Journal of Nutritional Biochemistry |
| Appears in Collections: | Artigo de Periódico |
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