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Type:	Artigo de Periódico
Title:	Inhibition of GATA3, ABCB1, and TYR by gallic acid: a real-world approach to uncovering a preventive agent against oral squamous cell carcinoma development
Authors:	Osvaldo Sena Guimarães Lílian Mendes Borburema Cangussu Lorena dos Reis Pereira Queiroz Eliane Macedo Sobrinho Santos Marcela Gonçalves de Souza Alfredo Maurício Batista de Paula Lucyana Conceição Farias Sérgio Henrique Sousa Santos Marcos Flávio Silveira Vasconcelos D'Angelo André Luiz Sena Guimarães
Abstract:	Objective: this study aimed to the efficacy of gallic acid (GA) as a prospective prophylactic agent against the onset of oral squamous cell carcinoma (OSCC). Methods: we conducted bioinformatic analyses to identify the molecular targets of GA. Subsequently, we employed the 4NQO-induced animal model to evaluate the therapeutic potential of GA in OSCC. Results: our analysis unveiled that only three genes, ABCB1, GATA3, and SERPINE1, were associated with survival outcomes in OSCC patients. Reduced expressions of ABCB1 and GATA3 correlated with hazard ratios of 1.53 and 2.06, respectively, for mortality, while elevated SERPINE1 expression carried a 1.42-fold increased risk of death in OSCC patients. Molecular docking simulations underscored the robust affinity between GA and these genes, revealing binding energies of −6.0 kcal/mol for ABCB1, − 6.1 kcal/mol for GATA3, and −5.9 kcal/mol for SERPINE1. Furthermore, GA treatment demonstrated statistically significant reductions in the histopathological grade of 4NQO-induced lesions (p = 0.006) and mitigated liver (p < 0.001) and kidney (p < 0.001) toxicity associated with 4NQO exposure. Conclusion: the current study highlights GA as a promising contender for OSCC prevention. Mainly, GA targets critical genes such as ABCB1, GATA3, and SERPINE1, substantially impacting patient survival. Furthermore, GA administration mitigates 4NQO-induced toxicity, indicating its potential to improve animal survival by reducing lesion severity. These findings carry significant implications for OSCC research and potential clinical applications.
Subject:	Cabeça - Câncer Pescoço - Câncer Carcinoma de células escamosas Ácido gálico Polifenóis Bioinformática
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.genrep.2023.101840
URI:	http://hdl.handle.net/1843/77365
Issue Date:	Dec-2023
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S2452014423001024
metadata.dc.relation.ispartof:	Gene Reports
Appears in Collections:	Artigo de Periódico

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