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http://hdl.handle.net/1843/77854| Type: | Artigo de Periódico |
| Title: | Use of cytological smear and cell block technique for the diagnosis of plasma cell myeloma infiltration in the mandible |
| Authors: | Fernanda Aragão Felix Ana Carolina Velasco Pondé de Sena Thalita Soares Tavares Denise Vieira Travassos Fernanda Pereira Delgado Costa Ricardo Alves de Mesquita Tarcília Aparecida da Silva |
| Abstract: | Fine-needle aspiration cytology (FNAC) is a diagnostic tool using a needle to collect samples for cytopathological examina tion. We report a case of a 49-year-old male patient with previ ous medical history of plasma cell myeloma (PCM), who had osteolytic lesions in the mandible, diagnosed by FNAC. Imaging exams exhibited multiple osteolytic lesions with ill-defined mar gins in the bilateral mandibular body. FNAC of the intraosseous lesion of the mandible was performed. Cytological smear and cell block technique revealed plasma cells in different degrees of maturation, predominantly eccentric pleomorphic nuclei and abundant, eosinophilic cytoplasm without a paranuclear halo. Immunohistochemistry exhibited positivity for CD138, lambda light chain and Ki-67 (proliferation index was »50%). Based on clinicoradiographic, microscopic, and biochemical findings, the diagnosis was PCM infiltration in the mandible. The patient underwent chemotherapy and autologous hematopoietic stem cell transplantation, and had partial remission after 10 months of follow-up. |
| Subject: | Drug Therapy Cytology Diagnosis Multiple myeloma Hematopoietic stem cell transplantation Syndecan-1 Ki-67 antigen Immunohistochemistry |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA FAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.oooo.2023.03.035 |
| URI: | http://hdl.handle.net/1843/77854 |
| Issue Date: | Jul-2023 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S2212440323001463 |
| metadata.dc.relation.ispartof: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Appears in Collections: | Artigo de Periódico |
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